Available Technologies

Mouse model of Alzheimer’s disease

Unmet Need Alzheimer’s disease is a neurodegenerative disease marked by loss of cognitive function. There is currently no cure for Alzheimer’s disease. In fact, the limited therapies available only alleviate symptoms for a short time…

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Enclosure device to track fine-scale movements of animals in 3D with a single camera

Unmet Need A major component of medical research and preclinical drug development is to identify subtle behavioral phenotypes in animal models. This has led to progress in studies of depression, anxiety, cognitive disorders, and neurological…

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Use of sustained-release 5-hydroxytrypophan in treating constipation

Unmet Need Over 10% of the population suffers from constipation disorders, with irritable bowel syndrome-constipation and chronic idiopathic constipation being the most prevalent diagnoses. Current treatment options for constipation are available over-the-counter by prescription. However,…

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A mouse strain lacking functional GRK4 gene

GRK4 is prominently expressed in testes, with expression also in select brain regions (cerebellum) and other organs and cell types. GRK4 has been implicated in regulation of cerebellar mGluRl and GABA, receptors, and may be…

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Activated caspase-3 reporter mouse

The activated caspase-3 reporter mouse is an in vivo screening assay for apoptosis (regulated, energy-dependent cell death) in all tissues. Fluorescence miscroscopy of the fluorophore mCerulean reveals levels of caspase-3 activation in cells, and hence…

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ZIP fish: zebrafish insulin promoter

Duke scientists have created stable transgenic zebrafish with strict pancreatic, beta cell-specific expression of GFP in embryos, larvae and adult. This model can serve as a high throughput screen for diabetic drugs.

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Transgenic mice expressing mutant pig rhodopsin

Value Proposition ADRP (Autosomal Dominant Retinitis Pigmentosa) is a type of retinal degeneration that affects 1 in 3500 people worldwide and is caused by mutations in the rhodopsin gene 30% of the time. Suitable animal…

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Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment

Value Proposition Defects in acetylcholine transmission have been associated with several major neurodegenerative disorders including Alzheimer’s disease, dementia, cerebral palsy, Parkinson’s disease, Huntington’s disease and myasthenia gravis. Although cholinergic dysfunction has been implicated in these…

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Genes involved in the pathogenesis of anxiety disorders including obsessive-compulsive disorder

Anxiety disorders are the most common mental illness in the US, affecting 18% of the population. Obsessive compulsive disorder (OCD), in particular, is one of the most disabling with a diminished quality of life. Only…

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Shank3 knockout mice as a model for autism

The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated…

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Ager-CreERT2 allele knock-in mouse model

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