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Solid-Phase Alkyl Aryl Mixed Disulfides for Highly Efficient Cysteine/Thiol Immobilization
Technology The inventors have developed a strategy for purification of post-translationally modified peptides or proteins, and the identification of the various modifications. The methodology involves solid-phase immobilization of cysteine/thiol groups using mixed disulfides of resin-bound…
A 3D tissue model for evaluating lymphovascular invasion of breast cancer cells
Value proposition Tissue engineering is an emerging market expected to witness significant growth over the next few years, with a CAGR of approximately 34.9%. There are many applications of tissue engineering, including the development of…
Transgenic mice expressing mutant pig rhodopsin
Value Proposition ADRP (Autosomal Dominant Retinitis Pigmentosa) is a type of retinal degeneration that affects 1 in 3500 people worldwide and is caused by mutations in the rhodopsin gene 30% of the time. Suitable animal…
A cDNA clone encoding a functional L-proline transporter expressed in rat brain
Value Proposition The L-proline transporter is expressed in several subpopulations of glutamatergic neurons and is implicated in higher cortical functions and memory. Several CNS disorders are associated with L-proline transporter abnormalities, and thus tools for…
An expressible antidepressant-sensitive serotonin transporter
Value Proposition Serotonin-targeting antidepressants are now prescribed for a wide spectrum of disorders, including obsessive-compulsive disorder, depression, as well as eating, sleep, and panic disorders. Next generation therapeutic strategies to combat these disorders, and to…
A cDNA sequence encoding the ATX protein (Human ATX cDNA)
Value Proposition ATX is an active protein kinase that plays a role in cellular stress responses, and defects in ATX also play a role in the development of cancer and other proliferative disorders. Thus, small…
A murine monoclonal antibody for human myeloid cells (9E1 DU-HL60-3)
Value Proposition The development of technology to produce monoclonal antibodies for the immunological detection of cell membrane antigens has been extensively applied to the identification of human lymphocyte cell surface antigens. Monoclonal antibodies reactive with…
Human A1 adrenergic receptor genes
Value Proposition Alpha 1-Adrenergic receptors (alpha 1ARs) are virtually ubiquitous in human tissues and play roles in several important physiological functions such as smooth muscle contraction, glycogenolysis, and myocardial inotropy. Alpha blockers in current clinical…
A plasmid which overproduces the Tet(M) resistance protein (pSH52)
Value Proposition Bacterial resistance to current therapies remains a clinical challenge. For example, numerous enterococcal, staphylococcal, and streptococcal bacterial species are known to exhibit resistance to potent antibacterial tetracycline through upregulation of a ribosomal protection…
A monoclonal antibody specific for CD166 (3A6: mAb to CD166, ALCAM)
Value Proposition CD166 is a leukocyte cell adhesion molecule known to play a role in diseases such as rheumatoid arthritis, certain cancers such as colorectal carcinoma and breast cancer, and select autoimmune diseases. Technologies to…
Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…