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MP399 Cell Line
MP399 is a fully characterized myeloma cell line established from a patient with plasma cell leukemia. It has been successfully used to test a drug with anti-myeloma activity in-vitro. Subsequently and based on our preliminary…
p3.1-64A-MART-A27L
The plasmid is used for in vitro transcription of RNA encoding the Melan A/ MART-1 human melanoma antigen with an alanine to leucine mutation at the 27th amino acid of the protein.
A mouse strain lacking functional GRK4 gene
GRK4 is prominently expressed in testes, with expression also in select brain regions (cerebellum) and other organs and cell types. GRK4 has been implicated in regulation of cerebellar mGluRl and GABA, receptors, and may be…
Activated caspase-3 reporter mouse
The activated caspase-3 reporter mouse is an in vivo screening assay for apoptosis (regulated, energy-dependent cell death) in all tissues. Fluorescence miscroscopy of the fluorophore mCerulean reveals levels of caspase-3 activation in cells, and hence…
ZIP fish: zebrafish insulin promoter
Duke scientists have created stable transgenic zebrafish with strict pancreatic, beta cell-specific expression of GFP in embryos, larvae and adult. This model can serve as a high throughput screen for diabetic drugs.
The production of hyperpolarized 15N2 gas and molecular probes for use in magnetic resonance imaging
Unmet Need Magnetic resonance (MR) is a valuable tool for studying the structure, function, and dynamics of molecular species both in vitro and in vivo. However, conventional MR suffers from poor sensitivity at thermal equilibrium.…
Solid-Phase Alkyl Aryl Mixed Disulfides for Highly Efficient Cysteine/Thiol Immobilization
Technology The inventors have developed a strategy for purification of post-translationally modified peptides or proteins, and the identification of the various modifications. The methodology involves solid-phase immobilization of cysteine/thiol groups using mixed disulfides of resin-bound…
A 3D tissue model for evaluating lymphovascular invasion of breast cancer cells
Value proposition Tissue engineering is an emerging market expected to witness significant growth over the next few years, with a CAGR of approximately 34.9%. There are many applications of tissue engineering, including the development of…
A cDNA clone encoding a functional L-proline transporter expressed in rat brain
Value Proposition The L-proline transporter is expressed in several subpopulations of glutamatergic neurons and is implicated in higher cortical functions and memory. Several CNS disorders are associated with L-proline transporter abnormalities, and thus tools for…
A monoclonal antibody specific for CD166 (3A6: mAb to CD166, ALCAM)
Value Proposition CD166 is a leukocyte cell adhesion molecule known to play a role in diseases such as rheumatoid arthritis, certain cancers such as colorectal carcinoma and breast cancer, and select autoimmune diseases. Technologies to…
An expressible antidepressant-sensitive serotonin transporter
Value Proposition Serotonin-targeting antidepressants are now prescribed for a wide spectrum of disorders, including obsessive-compulsive disorder, depression, as well as eating, sleep, and panic disorders. Next generation therapeutic strategies to combat these disorders, and to…