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Harmonic acoustofluidics for non-contact, dynamic, selective (HANDS) particle manipulation
Unmet Need Precise and selective manipulation of microscale particles and cells in liquid suspension (colloidal mixture) is a challenge in the fields of biomedicine and materials science. Current methods for the assembly of colloidal matter…
A platform for high-throughput quantification of gap junction hemichannel docking
Unmet Need Gap junctions are transmembrane channels that facilitate for cell-cell communication. They play a crucial role in normal cellular physiology and their dysfunction or misregulation is associated with many human diseases. Gap junctions are…
Method for increasing gene expression in mammalian cells from transfected plasmids
Unmet Need Mammalian cell-based protein expression systems enable the production of mammalian proteins in the most native structure and activity. Thus, they have been commonly used for producing antibodies and therapeutic proteins, and more recently,…
Mouse model of Alzheimer’s disease
Unmet Need Alzheimer’s disease is a neurodegenerative disease marked by loss of cognitive function. There is currently no cure for Alzheimer’s disease. In fact, the limited therapies available only alleviate symptoms for a short time…
Enclosure device to track fine-scale movements of animals in 3D with a single camera
Unmet Need A major component of medical research and preclinical drug development is to identify subtle behavioral phenotypes in animal models. This has led to progress in studies of depression, anxiety, cognitive disorders, and neurological…
Use of sustained-release 5-hydroxytrypophan in treating constipation
Unmet Need Over 10% of the population suffers from constipation disorders, with irritable bowel syndrome-constipation and chronic idiopathic constipation being the most prevalent diagnoses. Current treatment options for constipation are available over-the-counter by prescription. However,…
Near-infrared fluorescent proteins for live cell and animal imaging
Unmet Need Fluorescent microscopy is one of the most common research tools used by biologists and has a global market value expected to exceed $768 million by 2023. Many of the currently available fluorescent protein…
Acoustofluidic centrifuge for nanoparticle enrichment and separation
Unmet Need Nanoparticle manipulation is highly relevant to biomedical and biochemical fields, and the ability to perform nanoparticle concentration and separation has emerged as a critical need in various settings such as point-of-care diagnostics, bioassays,…
HIV-1 incidence biomarkers
Background Measures of HIV incidence are used to help public health officials, researchers, and policy makers monitor the epidemic, evaluate the impact of interventions, and assist in the identification of sites for HIV prevention trials.…
System for detecting three protein-protein interactions in living cells
Unmet Need Recognizing Protein-Protein Interactions (PPIs) is central to many molecular biology studies aiming to identify important targets for the development of therapeutic drugs. There are thousands of PPIs that are essential to understand the…
Detection and measurement of RNA modifications through targeted RNA editing
Value Proposition N6-methyladenosine, m6A, is the most frequent post-transcriptional modification in RNA that has been implicated in nearly every aspect of the RNA life cycle. Furthermore, proteins involved in the formation, removal, and recognition of…
CRISPR-based antiviral treatment of coronavirus infections
Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…