Duke OTC Technologies

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A plate assay for in situ imaging of microbial growth in biofilms

Unmet Need As the study of antimicrobial-resistant biofilms becomes increasingly relevant, there is a need for a microplate assay that allows for continuous monitoring of biofilm formation by confocal laser scanning microscopy (CLSM). Microplate assays…

Plasmids for the overexpression of GPCRs

Technology Duke inventors have generated four novel GPCR plasmids that can be used for the stable overexpression of several GPCRs: pcDNA3-Flag-β2AR pcDNA3-hAT1R (human) pcDNA3-HA-rATlaR (rat) pcDNA3-Flag-rATlaR (rat)

Cell lines for the overexpression of GPCRs

Technology Duke inventors have generated five novel cell lines that can be used for the stable overexpression of several GPCRs: HEK293-rATlaR (2pM/mg) HEK293-rATlaR (600fM/mg) NIH-3T3-Flag-Smo 1.1 NIH-3T3-Flag-Smo 1.7 HEK293-Flag-β2AR (2pM/mg, W9)

B-arrestin 1 and 2 conditional knockout mouse models

Technology Duke inventors have created two novel mouse lines for the acute ablation of β-arrestin 1 or β-arrestin 2: Conditional Flox/Cre (tet inducible) β-arrestin 1 KO mice (C57/BL6J background) Conditional Flox/Cre (tet inducible) β-arrestin 2…

B-arrestin biosensor cell lines

Technology Duke inventors have created 14 novel biosensor cell lines that can be used for the detection of translocation events, generation of signaling messages, and protein-protein interactions within cells: U2OS-βarrestin2-YFP U2OS-βarrestin1-YFP 293-βarrestin2-YFP 293-βarrestin1-YFP NIH-3T3-Smo-GFP HEK293-rATlaR-CFP,…

Plasmids for the expression of B-arrestins and GRKs

Technology Duke inventors have generated 12 novel plasmids that can be used for the expression of β-arrestins and GRKs: pCDNA3-βarrestin1-Flag pCDNA3-βarrestin2-Flag pGEX-5G/LIC-βarrestin1 pGEX-5G/LIC-βarrestin2 pGEX-4T1-βarrestin1 C-terminus pGEX-4T1-βarrestin2 C-terminus pRK5-bGRK2 pRK5-bGRK3 pRK5-bGRK4 pRK5-hGRK5 pRK5-hGRK6 pRK5-hGRK26caax

Plasmids with RNA aptamers to B-arrestin

Technology Duke inventors have created 10 novel plasmids which can be used for the production of RNA aptamers to β-arrestins through in vitro translation: pCR-TOPO-8R1-36 pCR-TOPO-8R2-1 pCR-TOPO-8R2-15 pCR-TOPO-8R2-16 pCR-TOPO-8R2-20 pCR-TOPO-8R2-21 pCR-TOPO-8R2-24 pCR-TOPO-11R2-5 pCR-TOPO-11R2-7 pCR-TOPO-11R2-15

Transgenic zebrafish to direct epicardial gene expression

Technology Duke inventors have generated a novel zebrafish model that allows researchers to study epicardial cells during embryonic heart development and myocardial regeneration. This zebrafish line is termed Tg(tcf21:CreER)pd42. Specifically, this transgenic model was created…

iPSC line to identify novel therapies for ARVC

Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…