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RNA switch enabling stress-responsive regulation of protein expression for safer, more consistent gene and mRNA therapies
Unmet Need Current gene and mRNA therapies lack mechanisms to regulate protein expression in response to intracellular stress. Overexpression of therapeutic proteins can induce ER stress leading to unfolded proteins that do more harm than…
Precision Engineering of Neural Circuits via Designer Connexins for Long-Term Cellular Integration
Unmet Need Gap junctions are crucial for enabling the direct flow of ions and small molecules between cells, playing a significant role in synchronizing electrical activity in organs like the heart and brain. However, mutations…
Automated cell membrane tension controller for studying mechanotransduction
Unmet Need Force-gated ion channels embedded in the cell membrane are central to mechanotransduction – the process by which mechanical forces are converted into electrochemical signals that regulate cellular behaviors such as motility, adhesion, and…
Next-Generation Protein Linkers: Enhancing Stability and Targeting in Bioengineered Therapeutics
Unmet Need In protein bioengineering, stable and effective fusion proteins are crucial for therapeutic and diagnostic applications. However, current protein linkers often fail to maintain the stability, bioactivity, and targeted functionality needed, leading to limitations…
Method to identify and design activation domains of plant transcription factors
Unmet Need The rise in the human population and a changing climate have placed increased strain upon the agricultural sector to produce high quality and high yield crops. This has led for a push to…
Methods and compositions for treating protein aggregation diseases
Unmet Need Neurodegenerative disease affects more than 50 million people per year. Certain neurodegenerative diseases, like Alzheimer’s disease, result from the accumulation of amyloid-forming proteins in the brain, which results in cognitive impairment and has…
Detection and measurement of RNA modifications through targeted RNA editing
Value Proposition N6-methyladenosine, m6A, is the most frequent post-transcriptional modification in RNA that has been implicated in nearly every aspect of the RNA life cycle. Furthermore, proteins involved in the formation, removal, and recognition of…
A method for identifying sour-taste receptor ligands as well as compounds that modulate their activity
Unmet Need The taste system is essential for feeding and survival as it helps humans evaluate the nutritional content in food. Every year, taste and smell dysfunctions affect more than 200,000 people, including those undergoing…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
An integrated hybrid biological-materials platform for portable production of biomacromolecules
Value Proposition Bacteria are a common host to produce diverse biologics, accounting for ~30% of biopharmaceuticals. The industrial synthesis of recombinant proteins using bacterial hosts entails multiple steps that each require a sophisticated and delicate…
SUMO as a marker of cancer development and target for cancer therapy
Value Proposition Cancer therapy remains challenging, and the production of new inhibitor therapies is stinted by the need for clear successful targets that will block tumor cell proliferation. Small ubiquitin-like modifier (SUMO) proteins and the…
Aptamers to VMF
Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific…