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A plate assay for in situ imaging of microbial growth in biofilms
Unmet Need As the study of antimicrobial-resistant biofilms becomes increasingly relevant, there is a need for a microplate assay that allows for continuous monitoring of biofilm formation by confocal laser scanning microscopy (CLSM). Microplate assays…
Portable mass spectrometer with high sensitivity and resolution
Unmet Need Mass spectrometry is a method of particle composition analysis. Traditionally, mass spectrometers are large devices with high energy requirements, restricting them to high-resource laboratory settings. Mass spectrometry can be used for isotopic analysis…
A robust and sensitive assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts
Unmet Need Cis-regulatory elements (cREs) of the genome are non-coding regions that play essential roles in regulating gene expression in development and disease. Importantly, these regions are characterized by the presence of “open” chromatin and…
Harmonic acoustofluidics for non-contact, dynamic, selective (HANDS) particle manipulation
Unmet Need Precise and selective manipulation of microscale particles and cells in liquid suspension (colloidal mixture) is a challenge in the fields of biomedicine and materials science. Current methods for the assembly of colloidal matter…
Solid-Phase Alkyl Aryl Mixed Disulfides for Highly Efficient Cysteine/Thiol Immobilization
Technology The inventors have developed a strategy for purification of post-translationally modified peptides or proteins, and the identification of the various modifications. The methodology involves solid-phase immobilization of cysteine/thiol groups using mixed disulfides of resin-bound…
A fluorescent probe for monitoring beta-secretase activity in cells
Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By…
Two dimensional electrophoresis cassette
A device for two-dimensional electrophoresis includes a cassette comprising two opposing plates. The two opposing plates form a first elongated portion for receiving a first elongated electrophoretic separation medium and a second portion extending away…
Test of Verbal Expression and Reasoning (TOVER)
The TOVER is non-standardized assessment of expressive language in context and verbal reasoning. The 64 item test was specifically designed to assess language function in children and adults with Down syndrome across a broad range…