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Methods for freeze-drying hydrogel microparticles

Methods for freeze-drying hydrogel microparticles

Unmet Need Biomaterial gels are appealing for several applications including tissue mimics, drug delivery, and regenerative medicine. Specifically, microporous annealed particle gels are porous biomaterial scaffolds comprised of spherical hydrogel based microparticles interconnected to form…

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A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals

A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals

Unmet Need In the past three decades implanted neurostimulation devices have become widely adopted driven largely by their ability to treat a range of clinical conditions with a “drug-free” solution. The $6.6 billion dollar market…

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Implant for identifying sites of seizure onset in the brain

Implant for identifying sites of seizure onset in the brain

Unmet Need In the United States, epilepsy affects 2.2 million people with 150,000 new cases each year. Between 14.6% and 36.3% of people who suffer from epilepsy have forms of epilepsy that are not controllable…

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An effective method for treating functional gastrointestinal and motility disorders using patterned electrical stimulation in the colon

An effective method for treating functional gastrointestinal and motility disorders using patterned electrical stimulation in the colon

Unmet Need Functional gastrointestinal and motility disorders (FGIMD) impact 1 in 5 persons in the U.S. It is a group of disorders classified by GI symptoms which include irritable bowel syndrome, fecal incontinence, constipation, and…

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Bioresorbable lactone-based elastomers that can be used in continuous digital light processing 3D printing applications

Bioresorbable lactone-based elastomers that can be used in continuous digital light processing 3D printing applications

Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 21% predicted to occur until 2027. Medical and dental products account for the…

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A method to improve deep brain stimulation treatments by using cortical evoked potentials as a biomarker

A method to improve deep brain stimulation treatments by using cortical evoked potentials as a biomarker

Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…

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A multi-electrode multiplexed channel brain-computer interface for patient assistive technologies

A multi-electrode multiplexed channel brain-computer interface for patient assistive technologies

Unmet Need According to the WHO, in 2019 neurological disorders were recognized as a growing public health challenge resulting in over 500,000 deaths globally. In the US alone, neurological diseases cause an estimated $800 billion-dollar…

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Tunable elastomer-like polymers for use in soft tissue regeneration and drug delivery

Tunable elastomer-like polymers for use in soft tissue regeneration and drug delivery

Unmet Need Biodegradable synthetic polymers are often used as scaffolding or support materials in tissue engineering and regenerative medicine. However, many of the materials that have been used widely, such as PLLA and PCL, do…

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Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications

Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications

Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 22.0% predicted to occur until 2024. Medical and dental products account for about…

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Improved beta oscillation burst detection for assessment of Parkinson’s disease

Improved beta oscillation burst detection for assessment of Parkinson’s disease

Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…

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Method to optimize spinal cord stimulation therapy placement and parameters

Method to optimize spinal cord stimulation therapy placement and parameters

Unmet Need Spinal cord stimulation (SCS) is an FDA approved therapy that stimulates the spinal cord using electrical pulses. This therapy is used to treat chronic pain, and it is estimated 50,000 spinal cord stimulating…

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A method to optimize neural activity blocking therapies

A method to optimize neural activity blocking therapies

Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…

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