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DU ALL 1 monoclonal antibody
DU ALL1 is a monoclonal antibody useful in the classification of human leukemias and as a cytoxic reagent for the elimination of leukemic cells in bone marrow transplantation studies.
Estrogen Receptor Action Indicator (ERIN) Mouse
To address globally the issue of tissue specificity of ER ligands, Duke scientists have developed a transgenic mouse that functions as a reporter of ER activity, termed ERIN (estrogen receptor action indicator). ERIN provides a…
Sublingual immunization using supramolecular peptide-polymer conjugate tablets
Value proposition Immunization with vaccines prevent illness, disability, and currently avert an estimated 2 to 3 million deaths every year. However, commonly-used vaccine technology platforms can be unpredictable, require a high manufacturing cost, and often…
Genetically encoded hybrid biomaterials that are thermally responsive and tunable
Unmet Need Developing new biomaterials is an active area of research, with applications in tissue engineering, regenerative medicine, and drug-delivery. In particular, protein- and peptide-based materials are attractive candidates for these applications because of their…
Method of synthesizing carbon nanotubes with enhanced electron field emission properties
Value Proposition Carbon nanotubes are cylindrical large molecules that possess exceptional thermal, mechanical, and electrical properties. Comparing with conventional electron emission materials, carbon nanotubes have been shown to be excellent electron field emitters, making them…
Scintillation materials and devices for high-resolution, high-sensitivity, ionizing radiation detectors
Value Proposition Many industries require radiation detection; everything from agriculture to oncology to manufacturing. The proposed Nano-scintillator Fiber Optic Dosimeter (NS-FOD) offers accurate radiation detective in an inexpensive and durable detector. The detector offers a…
Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…
Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions
Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…
A fluorescent probe for monitoring beta-secretase activity in cells
Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By…
Gene targeting to the ROSA26 locus
Plasmids for gene modification unitlizing zink finger sequences targeting ROSA locus. Publication: P Perez-Pinera, DG Ousterout, MT Brown, CA Gersbach. Gene Targeting to the ROSA26 Locus Directed by Engineered Zinc Finger Nucleases. Nucleic Acids Res…
Tunable metamaterial
Technology Metamaterial comprising a plurality of resonators disposed on a substrate, the substrate comprising a dielectric support layer and a relatively thin semiconductor layer, having a Schottky junction between at least one conducting resonator and…
Stable Cell lines expressing nAChR subunits
About Nicotinic Acetylcholine Receptors (nAChR) Nicotinic acetylcholine receptors (nAChR) are receptor proteins that respond to the neurotransmitter acetylcholine, and respond to drugs including nicotine. When nAChR are activated, the cells release dopamine and other neurotransmitters,…