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Isogenic HCT1116 cell lines with heterozygous or homozygous MLL2 inactivating mutation
HCT 116- MLL2 +/- line (MLL2 heterozygous knockout; two clones)- Deviced from the fibroblast- looking HCT116 line, a human colorectal cancer line which has wild-type MLL2 alleles. Genetic engineering was used to insert a DNA…
GAD67-GFP mice
This line of transgenic mice expresses GFP in newly generated dentate granule cclls in the hippocampus, the most prominent site of adult neurogenesis. Adult neurogenesis has been shown lo play important roles in learning, memory…
Drd1 a-tdTomato BAC transgenic mouse
Fluorescent transgene (tdTomato) identifies cells with expression of tbe type I dopamine receptor in living and fixed preparations and may be used to distinguish unique features of cells expressing the type I dopamine receptor. In…
Materials and methods to study nonsyndromic autism due to ANK2 mutation
Duke scientists have developed a first of its kind mouse model for human nonsyndromic autism due to ANK2 mutation that exhibits credible differences in socially related behavior as heterozygotes, identified a neurospecific ANK2 spliced variant…
Genetic control of neurol activity in mice conditionally expressing TRPV1
ROSA-stop flox-TRPV1-IRES-ECFP knock-in mice Background strain 129S1/SvlmJ Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Upon crossing to a…
Sublingual immunization using supramolecular peptide-polymer conjugate tablets
Value proposition Immunization with vaccines prevent illness, disability, and currently avert an estimated 2 to 3 million deaths every year. However, commonly-used vaccine technology platforms can be unpredictable, require a high manufacturing cost, and often…
Genetically encoded hybrid biomaterials that are thermally responsive and tunable
Unmet Need Developing new biomaterials is an active area of research, with applications in tissue engineering, regenerative medicine, and drug-delivery. In particular, protein- and peptide-based materials are attractive candidates for these applications because of their…
Method of synthesizing carbon nanotubes with enhanced electron field emission properties
Value Proposition Carbon nanotubes are cylindrical large molecules that possess exceptional thermal, mechanical, and electrical properties. Comparing with conventional electron emission materials, carbon nanotubes have been shown to be excellent electron field emitters, making them…
Scintillation materials and devices for high-resolution, high-sensitivity, ionizing radiation detectors
Value Proposition Many industries require radiation detection; everything from agriculture to oncology to manufacturing. The proposed Nano-scintillator Fiber Optic Dosimeter (NS-FOD) offers accurate radiation detective in an inexpensive and durable detector. The detector offers a…
Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…
Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions
Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…
A fluorescent probe for monitoring beta-secretase activity in cells
Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By…