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Novel biosensors made with non-fouling polymer materials
Unmet Need The advancement of personalized medicine and targeted therapies has led to growing interest in high-performance biosensors that detect the presence of target analytes in biological systems. Recently, with the commercial availability of semiconducting…
An injectable lubricant that is more lubricating with longer in vivo retention than hyaluronic acid
Unmet Need Hyaluronic acid (HA) is commonly used to treat lubrication deficiencies experienced in eyes, lungs, and other visceral organs. However, the short in vivo residence time of creates a persistent challenge when used as…
A class of biodegradable stealth polymers to improve drug delivery
Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…
Transgenic mice harboring CRISPR-based transcriptional activators
CRISPR-based tools for gene regulation have enabled new studies of gene function and the development of genetic therapies. However, these studies have largely been limited to experiments with cells in culture due to the limitations…
An injectable hydrogel scaffold that delivers gene therapies locally
Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…
An implanted biomaterial to accelerate bone healing
Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…
Photo-oxidants with comprehensive visible spectral coverage for energy conversion and catalysis
Unmet Need Photochemistry, or the use of light to promote chemical reactions, has only recently been adapted by pharmaceutical companies in the past 10 years due to the development of photoredox catalysts that utilize visible…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
A rapid and low-cost method for benchtop microfabrication of thermoplastic microdevices using UV light and miniaturization
Unmet Need Microfluidics has shown considerable promise for advancing biomedical research and improving diagnostics. Various methods for fabricating channels for microfluidic devices have been developed. However, the majority of micropatterning techniques are costly, time-consuming, and…
Peptide materials for immunomodulation
Value Proposition Glatiramoids are biomaterials synthesized for use as immunomodulators. Specifically, they are polypeptide mixtures with randomized amino acid sequences. Glatiramoids are currently FDA approved for use in multiple sclerosis. They have also been explored…
Genetic control of neurol activity in mice conditionally expressing TRPV1
ROSA-stop flox-TRPV1-IRES-ECFP knock-in mice Background strain 129S1/SvlmJ Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Upon crossing to a…
DU ALL 1 monoclonal antibody
DU ALL1 is a monoclonal antibody useful in the classification of human leukemias and as a cytoxic reagent for the elimination of leukemic cells in bone marrow transplantation studies.