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Transgenic mice harboring CRISPR-based transcriptional activators
CRISPR-based tools for gene regulation have enabled new studies of gene function and the development of genetic therapies. However, these studies have largely been limited to experiments with cells in culture due to the limitations…
An injectable hydrogel scaffold that delivers gene therapies locally
Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…
An implanted biomaterial to accelerate bone healing
Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…
Photo-oxidants with comprehensive visible spectral coverage for energy conversion and catalysis
Unmet Need Photochemistry, or the use of light to promote chemical reactions, has only recently been adapted by pharmaceutical companies in the past 10 years due to the development of photoredox catalysts that utilize visible…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
A rapid and low-cost method for benchtop microfabrication of thermoplastic microdevices using UV light and miniaturization
Unmet Need Microfluidics has shown considerable promise for advancing biomedical research and improving diagnostics. Various methods for fabricating channels for microfluidic devices have been developed. However, the majority of micropatterning techniques are costly, time-consuming, and…
Peptide materials for immunomodulation
Value Proposition Glatiramoids are biomaterials synthesized for use as immunomodulators. Specifically, they are polypeptide mixtures with randomized amino acid sequences. Glatiramoids are currently FDA approved for use in multiple sclerosis. They have also been explored…
DU ALL 1 monoclonal antibody
DU ALL1 is a monoclonal antibody useful in the classification of human leukemias and as a cytoxic reagent for the elimination of leukemic cells in bone marrow transplantation studies.
Estrogen Receptor Action Indicator (ERIN) Mouse
To address globally the issue of tissue specificity of ER ligands, Duke scientists have developed a transgenic mouse that functions as a reporter of ER activity, termed ERIN (estrogen receptor action indicator). ERIN provides a…
Isogenic HCT1116 cell lines with heterozygous or homozygous MLL2 inactivating mutation
HCT 116- MLL2 +/- line (MLL2 heterozygous knockout; two clones)- Deviced from the fibroblast- looking HCT116 line, a human colorectal cancer line which has wild-type MLL2 alleles. Genetic engineering was used to insert a DNA…
GAD67-GFP mice
This line of transgenic mice expresses GFP in newly generated dentate granule cclls in the hippocampus, the most prominent site of adult neurogenesis. Adult neurogenesis has been shown lo play important roles in learning, memory…
Drd1 a-tdTomato BAC transgenic mouse
Fluorescent transgene (tdTomato) identifies cells with expression of tbe type I dopamine receptor in living and fixed preparations and may be used to distinguish unique features of cells expressing the type I dopamine receptor. In…