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Biomaterial therapy for healing brain tissue after ischemic stroke

Biomaterial therapy for healing brain tissue after ischemic stroke

Unmet Need Ischemic stroke affects 692,000 patients annually in the United States, and can result in paralysis and complications related to cognition and motor function. After a stroke, scarring and atrophy can occur at the…

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Biomaterial pouch for long-term xenogeneic cell transplantation

Biomaterial pouch for long-term xenogeneic cell transplantation

Unmet Need Cell therapy is an exciting therapeutic approach that is growing rapidly – there are more than 1,000 cell therapy clinical trials that are currently active in many different fields like oncology, neurology, hematology,…

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Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy

Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy

Unmet Need In the United States alone, over 1.8 million new patients were diagnosed with cancer in 2021, and over 600,000 patients died from the disease. Cytostatic nucleotides, such as gemcitabine and 5-fluorouracil, have been…

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Transparent silver nanowire composite film and method of application for flexible touch screens

Transparent silver nanowire composite film and method of application for flexible touch screens

Unmet Need Current flexible touch screens employ complex haptic feedback for user perception and nanowire mesh materials that have high fog leading to decreased visual acuity. With a flexible display market expected to reach $65.3…

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Sugar-based polymers with easily tuned mechanical properties that range from plastic to elastomeric

Sugar-based polymers with easily tuned mechanical properties that range from plastic to elastomeric

Unmet Need The production of plastics from renewable sources is one of the fastest-growing materials sectors. Bioplastics offer an alternative to the use of petroleum as a feedstock, which suffers from a variety of disadvantages…

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A room temperature method for producing noble-metal coated copper nanowires that maintains the optoelectronic properties of noble-metal wire at a lower cost

A room temperature method for producing noble-metal coated copper nanowires that maintains the optoelectronic properties of noble-metal wire at a lower cost

Unmet Need Transparent conductors are necessary components for smartphones, organic photovoltaics (OPVs), organic light emitting diodes (OLEDs), flat panel displays, and touch sensors. Indium tin oxide (ITO) is the chief material utilized for this purpose…

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Acoustic imaging with metamaterial Luneburg lenses

Acoustic imaging with metamaterial Luneburg lenses

Unmet Need Controlling and focusing acoustic waves is a crucial component of fields such as ultrasonic sensing and speaker system design. Luneburg lenses, spherically symmetrical gradient refractive index (GRIN) devices with unique imaging properties, are…

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Acoustic lensing and holographic reconstruction with metamaterials

Acoustic lensing and holographic reconstruction with metamaterials

Unmet Need Manipulation of sound waves in air often requires many amps, transducers, and the electronics to control them, making applications like ultrasonic sensors for cars and wireless power transfer complex and power intensive. Acoustic…

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A green and efficient free radical initiator system for producing hydrogels

A green and efficient free radical initiator system for producing hydrogels

Unmet Need Hydrogels are heavily employed in agriculture, commercial wound dressings, and hygienic products, with more recent development in biomedical applications, including drug delivery, bioelectronics, bioimaging, and tissue engineering. Free radical polymerization is one of…

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Novel biosensors made with non-fouling polymer materials

Novel biosensors made with non-fouling polymer materials

Unmet Need The advancement of personalized medicine and targeted therapies has led to growing interest in high-performance biosensors that detect the presence of target analytes in biological systems. Recently, with the commercial availability of semiconducting…

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An injectable lubricant that is more lubricating with longer in vivo retention than hyaluronic acid

An injectable lubricant that is more lubricating with longer in vivo retention than hyaluronic acid

Unmet Need Hyaluronic acid (HA) is commonly used to treat lubrication deficiencies experienced in eyes, lungs, and other visceral organs. However, the short in vivo residence time of creates a persistent challenge when used as…

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A class of biodegradable stealth polymers to improve drug delivery

A class of biodegradable stealth polymers to improve drug delivery

Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…

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