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Viral-mediated humanized mouse model for Parkinson’s disease
Unmet Need Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain and the accumulation of α-synuclein aggregates (Lewy bodies), leading to motor and cognitive impairments. PD…
Sugar-based polymers with easily tuned mechanical properties that range from plastic to elastomeric
Unmet Need The production of plastics from renewable sources is one of the fastest-growing materials sectors. Bioplastics offer an alternative to the use of petroleum as a feedstock, which suffers from a variety of disadvantages…
Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 22.0% predicted to occur until 2024. Medical and dental products account for about…
Bioresorbable lactone-based elastomers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 21% predicted to occur until 2027. Medical and dental products account for the…
Solvent Free Resorbable Resin for 3D Printing
Unmet Need Biologically resorbable resins have allowed for incredible advances in 3D printed implantable device technology. Bone implants, stents, drug delivery scaffolds, and many other lifesaving devices can be custom printed to meet a patient’s…
Elastomer films with strain-induced color change to detect functional failures
Unmet Need Elastomers are polymer materials that can recover their original shape after being deformed. These materials, such as rubber or some plastics, are widely used in industrial and commercial applications in the automobile and…
Zwitterionic-coated surgical mesh to minimize intra-abdominal adhesions
Unmet Need Four million abdominal surgeries are performed annually in the United States. Abdominal adhesions, or fibrous bands that bind tissue together, represent a significant postoperative complication occurring in >50% of patients undergoing abdominal surgery.…
iPSC line to identify novel therapies for ARVC
Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…
A synergistic chemotherapy and radiotherapy drug delivery technology for treating prostate cancer tumors
Unmet Need Pancreatic cancer is one of the deadliest manifestations of cancer in clinical oncology. Despite accounting for only 3.2% of all cancer cases, it is the third leading cause of cancer-related mortality. National Comprehensive…
Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy
Unmet Need In the United States alone, over 1.8 million new patients were diagnosed with cancer in 2021, and over 600,000 patients died from the disease. Cytostatic nucleotides, such as gemcitabine and 5-fluorouracil, have been…
A green and efficient free radical initiator system for producing hydrogels
Unmet Need Hydrogels are heavily employed in agriculture, commercial wound dressings, and hygienic products, with more recent development in biomedical applications, including drug delivery, bioelectronics, bioimaging, and tissue engineering. Free radical polymerization is one of…
Novel biosensors made with non-fouling polymer materials
Unmet Need The advancement of personalized medicine and targeted therapies has led to growing interest in high-performance biosensors that detect the presence of target analytes in biological systems. Recently, with the commercial availability of semiconducting…