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Genetic control of neurol activity in mice conditionally expressing TRPV1
ROSA-stop flox-TRPV1-IRES-ECFP knock-in mice Background strain 129S1/SvlmJ Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Upon crossing to a…
Sublingual immunization using supramolecular peptide-polymer conjugate tablets
Value proposition Immunization with vaccines prevent illness, disability, and currently avert an estimated 2 to 3 million deaths every year. However, commonly-used vaccine technology platforms can be unpredictable, require a high manufacturing cost, and often…
Genetically encoded hybrid biomaterials that are thermally responsive and tunable
Unmet Need Developing new biomaterials is an active area of research, with applications in tissue engineering, regenerative medicine, and drug-delivery. In particular, protein- and peptide-based materials are attractive candidates for these applications because of their…
Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…
Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions
Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…
Stable Cell lines expressing nAChR subunits
About Nicotinic Acetylcholine Receptors (nAChR) Nicotinic acetylcholine receptors (nAChR) are receptor proteins that respond to the neurotransmitter acetylcholine, and respond to drugs including nicotine. When nAChR are activated, the cells release dopamine and other neurotransmitters,…