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A class of biodegradable stealth polymers to improve drug delivery

A class of biodegradable stealth polymers to improve drug delivery

Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…

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Transgenic mice harboring CRISPR-based transcriptional activators

Transgenic mice harboring CRISPR-based transcriptional activators

CRISPR-based tools for gene regulation have enabled new studies of gene function and the development of genetic therapies. However, these studies have largely been limited to experiments with cells in culture due to the limitations…

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An injectable hydrogel scaffold that delivers gene therapies locally

An injectable hydrogel scaffold that delivers gene therapies locally

Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…

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An implanted biomaterial to accelerate bone healing

An implanted biomaterial to accelerate bone healing

Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…

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A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate

A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate

Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…

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Peptide materials for immunomodulation

Peptide materials for immunomodulation

Value Proposition Glatiramoids are biomaterials synthesized for use as immunomodulators. Specifically, they are polypeptide mixtures with randomized amino acid sequences. Glatiramoids are currently FDA approved for use in multiple sclerosis. They have also been explored…

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DU ALL 1 monoclonal antibody

DU ALL 1 monoclonal antibody

DU ALL1 is a monoclonal antibody useful in the classification of human leukemias and as a cytoxic reagent for the elimination of leukemic cells in bone marrow transplantation studies.

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Estrogen Receptor Action Indicator (ERIN) Mouse

Estrogen Receptor Action Indicator (ERIN) Mouse

To address globally the issue of tissue specificity of ER ligands, Duke scientists have developed a transgenic mouse that functions as a reporter of ER activity, termed ERIN (estrogen receptor action indicator). ERIN provides a…

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Isogenic HCT1116 cell lines with heterozygous or homozygous MLL2 inactivating mutation

Isogenic HCT1116 cell lines with heterozygous or homozygous MLL2 inactivating mutation

HCT 116- MLL2 +/- line (MLL2 heterozygous knockout; two clones)- Deviced from the fibroblast- looking HCT116 line, a human colorectal cancer line which has wild-type MLL2 alleles. Genetic engineering was used to insert a DNA…

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GAD67-GFP mice

GAD67-GFP mice

This line of transgenic mice expresses GFP in newly generated dentate granule cclls in the hippocampus, the most prominent site of adult neurogenesis. Adult neurogenesis has been shown lo play important roles in learning, memory…

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Drd1 a-tdTomato BAC transgenic mouse

Drd1 a-tdTomato BAC transgenic mouse

Fluorescent transgene (tdTomato) identifies cells with expression of tbe type I dopamine receptor in living and fixed preparations and may be used to distinguish unique features of cells expressing the type I dopamine receptor. In…

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Materials and methods to study nonsyndromic autism due to ANK2 mutation

Materials and methods to study nonsyndromic autism due to ANK2 mutation

Duke scientists have developed a first of its kind mouse model for human nonsyndromic autism due to ANK2 mutation that exhibits credible differences in socially related behavior as heterozygotes, identified a neurospecific ANK2 spliced variant…

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