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Adaptive Scanning for Framerate or Resolution Improvement with Point- and Line-Scan Imaging Modalities

Adaptive Scanning for Framerate or Resolution Improvement with Point- and Line-Scan Imaging Modalities

Unmet Need Optical Coherence Tomography (OCT) is a noninvasive imaging technology used to obtain high resolution cross-sectional images of biologic tissues, especially the retina. OCT testing has become a standard of care for the assessment…

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Quantitative polarization imaging with computational illumination

Quantitative polarization imaging with computational illumination

Unmet Need Quantitative polarimetric microscopy allows for high resolution imaging of structurally complex samples and can reveal fine anisotropic features of cells and materials. Current microscopes that image at micrometer-level detail can only observe a…

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Fiber optic probe with integrated photodetector capabilities

Fiber optic probe with integrated photodetector capabilities

Unmet Need Light-based diagnostics is a non-intrusive procedure that can be used to monitor chemotherapy treatment efficacy. Optical imaging additionally has the capacity for roles in diagnosis and surgery guidance. Currently, many devices for optic…

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An optical coherence tomography system capable of automatically and accurately imaging eyes without the use of chinrests

An optical coherence tomography system capable of automatically and accurately imaging eyes without the use of chinrests

Unmet Need Optical coherence tomography (OCT) has revolutionized structural imaging in the eye’s anterior segment and retina. Ophthalmologists now routinely employ OCT in managing ocular diseases, including age-related macular degeneration, diabetic retinopathy, glaucoma, and corneal…

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Computational methods to introduce image contrast from multidimensional data

Computational methods to introduce image contrast from multidimensional data

Unmet Need Three-dimensional (3D) imaging techniques, such as optical coherence tomography (OCT), have been successfully used as an in vivo diagnostic modality for a wide range of clinical areas including ophthalmology, cardiology, and gastroenterology. For…

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Automatic segmentation software to diagnose retinopathy of prematurity (ROP) from optical coherence tomography images in preterm infants

Automatic segmentation software to diagnose retinopathy of prematurity (ROP) from optical coherence tomography images in preterm infants

Unmet Need Retinopathy of prematurity (ROP) is a developmental vascular proliferative disorder that occurs in approximately 50-70% of preterm infants and is a leading cause of childhood blindness. The most critical factor in identifying ROP…

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Methods to implement three-dimensional (3D) sensing depth cameras

Methods to implement three-dimensional (3D) sensing depth cameras

Unmet Need Real-time high-resolution three-dimensional (3D) imaging is highly desirable in a wide range of fields including biomedical imaging, robotics, virtual/augmented reality, 3D printing, and autonomous vehicles. To accomplish 3D imaging, sensing depth cameras have…

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Efficient scan patterns for scanning laser microscopy systems

Efficient scan patterns for scanning laser microscopy systems

Unmet Need Scanning imaging systems, such as confocal scanning laser ophthalmoscopy (cSLO), hold great promise in the clinic to diagnose a variety of retinal disease like diabetic retinopathy. These systems are particularly promising for applications…

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Feature-Guided Image Fusion of Intrasurgical Optical Coherence Tomography and Digital Surgical Microscopy

Feature-Guided Image Fusion of Intrasurgical Optical Coherence Tomography and Digital Surgical Microscopy

Unmet Need Eye surgery is a high-impact intervention necessary to preserve the sight of thousands of patients, with retinal detachment surgeries alone constituting approximately 28,000 cases per year in the United States alone. Microscope-integrated optical…

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Void space and scaffold analysis of packed particles

Void space and scaffold analysis of packed particles

Unmet Need Granular materials are used in countless contexts and are appealing for several applications in biomedical engineering, including injectable tissue mimics and 3-D bioprinting. Packed microgel particles form granular scaffolds, which have been used…

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MRHistology complement to light sheet microscopy

MRHistology complement to light sheet microscopy

Unmet Need Brain researchers frequently rely on mouse models to conduct basic research on brain structure/function, pathology, connection, and a host of mouse models of neurologic disease. Light sheet microscopy is an emerging technology that…

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Smart microscope for diagnosing disease

Smart microscope for diagnosing disease

Value Proposition Since its invention, the microscope has been optimized for interpretation by a human observer. Recently, however, deep learning algorithms have been developed for automated image analysis in a variety of important contexts, such…

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