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A novel scanner design for ophthalmic OCT and hand-held OCT angiography
Value Proposition Angiography is a medical imaging technique used to visualize the inside of blood vessels and organs of the body. Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique of the retinal…
Void space and scaffold analysis of packed particles
Unmet Need Granular materials are used in countless contexts and are appealing for several applications in biomedical engineering, including injectable tissue mimics and 3-D bioprinting. Packed microgel particles form granular scaffolds, which have been used…
Enclosure device to track fine-scale movements of animals in 3D with a single camera
Unmet Need A major component of medical research and preclinical drug development is to identify subtle behavioral phenotypes in animal models. This has led to progress in studies of depression, anxiety, cognitive disorders, and neurological…
Near-infrared fluorescent proteins for live cell and animal imaging
Unmet Need Fluorescent microscopy is one of the most common research tools used by biologists and has a global market value expected to exceed $768 million by 2023. Many of the currently available fluorescent protein…
System for detecting three protein-protein interactions in living cells
Unmet Need Recognizing Protein-Protein Interactions (PPIs) is central to many molecular biology studies aiming to identify important targets for the development of therapeutic drugs. There are thousands of PPIs that are essential to understand the…
Optical device for in vivo assessment of tissues
Value Proposition Fluorescence and diffuse reflectance spectroscopy in the ultraviolet-visible (UV-VIS) spectrum are increasingly being investigated for tissue characterization. These biological scatterers, absorbers, and fluorophores may be used to indicate the existence of certain diseases.…
The production of hyperpolarized 15N2 gas and molecular probes for use in magnetic resonance imaging
Unmet Need Magnetic resonance (MR) is a valuable tool for studying the structure, function, and dynamics of molecular species both in vitro and in vivo. However, conventional MR suffers from poor sensitivity at thermal equilibrium.…
A fluorescent probe for monitoring beta-secretase activity in cells
Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By…
Test of Verbal Expression and Reasoning (TOVER)
The TOVER is non-standardized assessment of expressive language in context and verbal reasoning. The 64 item test was specifically designed to assess language function in children and adults with Down syndrome across a broad range…