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Feature-free photogrammetric 3D imaging with cameras under unconstrained motion

Feature-free photogrammetric 3D imaging with cameras under unconstrained motion

Unmet Need With the increasing development of camera-based sensors for applications such as virtual and augmented reality, there is more demand for technologies that can image 3D structures and create interpretable digital representations – a…

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A spatial coherence filtering method to increase resolution in color-flow ultrasound imaging

A spatial coherence filtering method to increase resolution in color-flow ultrasound imaging

Unmet Need Color-flow ultrasound imaging is a technique that allows for visualization of blood flow within tissues and is frequently used to diagnose cardiovascular abnormalities, guide needle biopsies, examine tumor vascularity, and measure blood flow…

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A microscopy method for acquiring polarization-sensitive phase information in 3D

A microscopy method for acquiring polarization-sensitive phase information in 3D

Unmet Need The majority of biological research and clinical diagnostics has involved the use of optical imaging systems for transparent specimens that rely on scalar properties like phase contrast. These systems have proved useful for…

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A computer vision approach for molecular subtyping of breast cancer using MRI

A computer vision approach for molecular subtyping of breast cancer using MRI

Unmet Need Breast cancer is the second leading cause of cancer-related deaths in American women and the fourth most common cause of all cancer-related deaths in the U.S. While early screening for cancer using magnetic…

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Multiscale coherence imaging for assessing epithelial tissue health in precancerous detection

Multiscale coherence imaging for assessing epithelial tissue health in precancerous detection

Unmet Need Epithelial cells act as the body’s first line of defense against foreign elements and are constantly being replaced by newly grown cells. Due in part to these factors, 90% of all cancers originate…

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A method for end-to-end spatial accuracy quality assurance for radiosurgery

A method for end-to-end spatial accuracy quality assurance for radiosurgery

Unmet Need Radiation therapy is an essential element of cancer treatment that benefits 4 million diagnosed patients every year. The ability to deliver complex three-dimensional distributions of dose that conform to even irregularly shaped lesions…

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A method for reducing speckle and improving resolution in ultrasound imaging

A method for reducing speckle and improving resolution in ultrasound imaging

Value Proposition For many years, ultrasound imaging has been an important and popular medical imaging method. The speckle texture in ultrasound images limits the detectability of low contrast targets. With size on the order of…

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Connecting cardiac and respiratory 3DCT imaging for 5DCT heart motion management

Connecting cardiac and respiratory 3DCT imaging for 5DCT heart motion management

Unmet Need Ventricular tachycardia (VT) is a primary condition of heart disease noted as an irregularity of heart rhythm due to improper electrical signaling in the ventricles that causes an abnormally high heart rate. VT…

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High-speed 3D tomographic imaging using a camera array

High-speed 3D tomographic imaging using a camera array

Unmet Need Tomographic imaging has revolutionized both scientific research and clinical procedures. 3D tomographic imaging reveals information about a sample’s volume, depth, and internal structures, which cannot be obtained from 2D imaging alone. However, 3D…

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Adaptive Scanning for Framerate or Resolution Improvement with Point- and Line-Scan Imaging Modalities

Adaptive Scanning for Framerate or Resolution Improvement with Point- and Line-Scan Imaging Modalities

Unmet Need Optical Coherence Tomography (OCT) is a noninvasive imaging technology used to obtain high resolution cross-sectional images of biologic tissues, especially the retina. OCT testing has become a standard of care for the assessment…

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Quantitative polarization imaging with computational illumination

Quantitative polarization imaging with computational illumination

Unmet Need Quantitative polarimetric microscopy allows for high resolution imaging of structurally complex samples and can reveal fine anisotropic features of cells and materials. Current microscopes that image at micrometer-level detail can only observe a…

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Fiber optic probe with integrated photodetector capabilities

Fiber optic probe with integrated photodetector capabilities

Unmet Need Light-based diagnostics is a non-intrusive procedure that can be used to monitor chemotherapy treatment efficacy. Optical imaging additionally has the capacity for roles in diagnosis and surgery guidance. Currently, many devices for optic…

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