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High-speed 3D tomographic imaging using a camera array
Unmet Need Tomographic imaging has revolutionized both scientific research and clinical procedures. 3D tomographic imaging reveals information about a sample’s volume, depth, and internal structures, which cannot be obtained from 2D imaging alone. However, 3D…
Adaptive Scanning for Framerate or Resolution Improvement with Point- and Line-Scan Imaging Modalities
Unmet Need Optical Coherence Tomography (OCT) is a noninvasive imaging technology used to obtain high resolution cross-sectional images of biologic tissues, especially the retina. OCT testing has become a standard of care for the assessment…
Quantitative polarization imaging with computational illumination
Unmet Need Quantitative polarimetric microscopy allows for high resolution imaging of structurally complex samples and can reveal fine anisotropic features of cells and materials. Current microscopes that image at micrometer-level detail can only observe a…
Fiber optic probe with integrated photodetector capabilities
Unmet Need Light-based diagnostics is a non-intrusive procedure that can be used to monitor chemotherapy treatment efficacy. Optical imaging additionally has the capacity for roles in diagnosis and surgery guidance. Currently, many devices for optic…
A novel scanner design for ophthalmic OCT and hand-held OCT angiography
Value Proposition Angiography is a medical imaging technique used to visualize the inside of blood vessels and organs of the body. Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique of the retinal…
An optical coherence tomography system capable of automatically and accurately imaging eyes without the use of chinrests
Unmet Need Optical coherence tomography (OCT) has revolutionized structural imaging in the eye’s anterior segment and retina. Ophthalmologists now routinely employ OCT in managing ocular diseases, including age-related macular degeneration, diabetic retinopathy, glaucoma, and corneal…
Computational methods to introduce image contrast from multidimensional data
Unmet Need Three-dimensional (3D) imaging techniques, such as optical coherence tomography (OCT), have been successfully used as an in vivo diagnostic modality for a wide range of clinical areas including ophthalmology, cardiology, and gastroenterology. For…
Automatic segmentation software to diagnose retinopathy of prematurity (ROP) from optical coherence tomography images in preterm infants
Unmet Need Retinopathy of prematurity (ROP) is a developmental vascular proliferative disorder that occurs in approximately 50-70% of preterm infants and is a leading cause of childhood blindness. The most critical factor in identifying ROP…
Methods to implement three-dimensional (3D) sensing depth cameras
Unmet Need Real-time high-resolution three-dimensional (3D) imaging is highly desirable in a wide range of fields including biomedical imaging, robotics, virtual/augmented reality, 3D printing, and autonomous vehicles. To accomplish 3D imaging, sensing depth cameras have…
Efficient scan patterns for scanning laser microscopy systems
Unmet Need Scanning imaging systems, such as confocal scanning laser ophthalmoscopy (cSLO), hold great promise in the clinic to diagnose a variety of retinal disease like diabetic retinopathy. These systems are particularly promising for applications…
Feature-Guided Image Fusion of Intrasurgical Optical Coherence Tomography and Digital Surgical Microscopy
Unmet Need Eye surgery is a high-impact intervention necessary to preserve the sight of thousands of patients, with retinal detachment surgeries alone constituting approximately 28,000 cases per year in the United States alone. Microscope-integrated optical…
Void space and scaffold analysis of packed particles
Unmet Need Granular materials are used in countless contexts and are appealing for several applications in biomedical engineering, including injectable tissue mimics and 3-D bioprinting. Packed microgel particles form granular scaffolds, which have been used…