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Portable mass spectrometer with high sensitivity and resolution
Unmet Need Mass spectrometry is a method of particle composition analysis. Traditionally, mass spectrometers are large devices with high energy requirements, restricting them to high-resource laboratory settings. Mass spectrometry can be used for isotopic analysis…
Harmonic acoustofluidics for non-contact, dynamic, selective (HANDS) particle manipulation
Unmet Need Precise and selective manipulation of microscale particles and cells in liquid suspension (colloidal mixture) is a challenge in the fields of biomedicine and materials science. Current methods for the assembly of colloidal matter…
Acoustofluidic centrifuge for nanoparticle enrichment and separation
Unmet Need Nanoparticle manipulation is highly relevant to biomedical and biochemical fields, and the ability to perform nanoparticle concentration and separation has emerged as a critical need in various settings such as point-of-care diagnostics, bioassays,…
Software for predicting vibrational blade response in gas turbines
Unmet Need Virtually all commercial aircraft use gas turbine engines and 90 percent of the world’s electricity is produced by turbines. One of the grand challenges in turbomachinery is to predict the vibratory response of…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
A fluorescent probe for monitoring beta-secretase activity in cells
Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By…
Test of Verbal Expression and Reasoning (TOVER)
The TOVER is non-standardized assessment of expressive language in context and verbal reasoning. The 64 item test was specifically designed to assess language function in children and adults with Down syndrome across a broad range…