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A fluorescent probe for monitoring beta-secretase activity in cells
Unmet Need Alzheimer’s Disease (AD) is characterized by the accumulation of amyloid-beta (Aβ) plaques, which lead to neurotoxicity, synaptic damage, and neuronal cell death. Current therapeutic approaches face significant challenges due to the complex nature…
Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis
Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…
A User-Customizable Modular Microplate Holder
Unmet Need Globally, laboratory accessories had an estimated market value of $504.7 million in 2020. Microplates and accessories represent 16% of this global market, which totals to $80.7 million. Manufacturers sell a variety of microplates…
Novel Self-Assembling Nanoparticles for Extended Duration Local Anesthetics
Unmet Need An estimated 40 million surgeries are performed every year in the United States. Out of this population, an estimated 80% had post-operative pain with 75% reporting it as moderate to extreme. Local anesthetics…
Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…
A 3D tissue model for evaluating lymphovascular invasion of breast cancer cells
Value proposition Tissue engineering is an emerging market expected to witness significant growth over the next few years, with a CAGR of approximately 34.9%. There are many applications of tissue engineering, including the development of…
An integrated hybrid biological-materials platform for portable production of biomacromolecules
Value Proposition Bacteria are a common host to produce diverse biologics, accounting for ~30% of biopharmaceuticals. The industrial synthesis of recombinant proteins using bacterial hosts entails multiple steps that each require a sophisticated and delicate…