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Morphological multiparameter filtration and persistent homology in mitochondrial image analysis
Unmet Need Current mitochondrial network analysis tools require significant manual intervention, making them labor-intensive, subjective, and prone to variability. These limitations hinder the reproducibility and accuracy needed for studying complex mitochondrial morphologies in disease diagnostics,…
FK506/FK520 analogs modified to increase fungal specificity and reduce immunosuppression
Unmet Need Fungal infections are becoming increasingly prevalent worldwide, with 150 million cases and 1.7 million fatalities reported in the last year alone. The challenge in treating these infections stems from the rise of multi-drug-resistant…
A fluorescent probe for monitoring beta-secretase activity in cells
Unmet Need Alzheimer’s Disease (AD) is characterized by the accumulation of amyloid-beta (Aβ) plaques, which lead to neurotoxicity, synaptic damage, and neuronal cell death. Current therapeutic approaches face significant challenges due to the complex nature…
Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis
Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…
A User-Customizable Modular Microplate Holder
Unmet Need Globally, laboratory accessories had an estimated market value of $504.7 million in 2020. Microplates and accessories represent 16% of this global market, which totals to $80.7 million. Manufacturers sell a variety of microplates…
Novel Self-Assembling Nanoparticles for Extended Duration Local Anesthetics
Unmet Need An estimated 40 million surgeries are performed every year in the United States. Out of this population, an estimated 80% had post-operative pain with 75% reporting it as moderate to extreme. Local anesthetics…
Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…
Structural variants of TERT in brain tumors
Unmet Need Glioblastoma is the most common type of malignant brain tumor, and accounts for 47.7% of all brain cancer cases. Despite aggressive treatment, the median overall survival for glioblastoma is 15 to 18 months.…
Gene therapy and small molecule treatment of chronic pain without addiction
Unmet Need Chronic pain is an escalating issue worldwide – in the U.S., an estimated one of five adults are affected. Chronic pain is difficult to treat, often requiring powerful opioids to provide relief. These…
Predicting immune checkpoint therapy for breast cancer patients using LRRK2 mutations
Unmet Need The treatment of various cancers has been revolutionized by the development of effective immunotherapies that are now established as powerful clinical tools. Unfortunately, it is also now well documented that only a minority…
Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury
Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…
Use of disulfiram for inflammatory breast cancer therapy
Value Proposition Inflammatory breast cancer is an aggressive and rapidly progressing form of breast cancer. It typically presents with rapid onset of painful primary skin changes and breast swelling, often without an obvious breast mass.…