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Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…

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Branched-chain amino acid metabolism: novel targets and interaction pathways

Branched-chain amino acid metabolism: novel targets and interaction pathways

Unmet Need Branched chain amino acids (BCAA) leucine, isoleucine, and valine are essential for human health. However, BCAA are also known to be strongly elevated in the context of metabolic disease such as obesity, type…

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Structural variants of TERT in brain tumors

Structural variants of TERT in brain tumors

Unmet Need Glioblastoma is the most common type of malignant brain tumor, and accounts for 47.7% of all brain cancer cases. Despite aggressive treatment, the median overall survival for glioblastoma is 15 to 18 months.…

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A process to selectively access allylic diamines that can aid in identifying new drug compounds

A process to selectively access allylic diamines that can aid in identifying new drug compounds

Unmet Need When developing new drugs, researchers often rely on naturally occurring compounds to learn what design features illicit a biological response that can be tailored for treating a given disease or ailment. However, reproducing…

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Gene therapy and small molecule treatment of chronic pain without addiction

Gene therapy and small molecule treatment of chronic pain without addiction

Unmet Need Chronic pain is an escalating issue worldwide – in the U.S., an estimated one of five adults are affected. Chronic pain is difficult to treat, often requiring powerful opioids to provide relief. These…

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Predicting immune checkpoint therapy for breast cancer patients using LRRK2 mutations

Predicting immune checkpoint therapy for breast cancer patients using LRRK2 mutations

Unmet Need The treatment of various cancers has been revolutionized by the development of effective immunotherapies that are now established as powerful clinical tools. Unfortunately, it is also now well documented that only a minority…

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Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury

Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury

Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…

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Fluorescence-based high-throughput assay for identifying antivirals to control COVID-19 pandemic

Fluorescence-based high-throughput assay for identifying antivirals to control COVID-19 pandemic

Unmet Need Current efforts to control COVID-19 are largely focused on behavioral modifications such as social distancing and the use of masks. These approaches attempt to slow the spread of the virus, but meaningful control…

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A simple method for creating a mass spectrometer that is preferentially sensitive to one or more compounds of interest

A simple method for creating a mass spectrometer that is preferentially sensitive to one or more compounds of interest

Value Proposition Mass spectrometers are used for all kinds of chemical analyses, ranging from environmental analysis to the analysis of petroleum products, trace metals and biological materials. Therefore, much of the utility associated with conventional…

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Use of disulfiram for inflammatory breast cancer therapy

Use of disulfiram for inflammatory breast cancer therapy

Value Proposition Inflammatory breast cancer is an aggressive and rapidly progressing form of breast cancer. It typically presents with rapid onset of painful primary skin changes and breast swelling, often without an obvious breast mass.…

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A 3D tissue model for evaluating lymphovascular invasion of breast cancer cells

A 3D tissue model for evaluating lymphovascular invasion of breast cancer cells

Value proposition Tissue engineering is an emerging market expected to witness significant growth over the next few years, with a CAGR of approximately 34.9%. There are many applications of tissue engineering, including the development of…

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An effective FASN inhibitor

An effective FASN inhibitor

Value Proposition Many tumors are dependent on de novo fatty acid synthesis as a source of long chain fatty acids to maintain growth and interdicting at key steps in this pathway may have therapeutic benefit.…

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