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Use of sustained-release 5-hydroxytrypophan in treating constipation

Use of sustained-release 5-hydroxytrypophan in treating constipation

Unmet Need Over 10% of the population suffers from constipation disorders, with irritable bowel syndrome-constipation and chronic idiopathic constipation being the most prevalent diagnoses. Current treatment options for constipation are available over-the-counter by prescription. However,…

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Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity

Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity

Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…

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Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions

Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions

Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…

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