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Bioresorbable lactone-based elastomers that can be used in continuous digital light processing 3D printing applications

Bioresorbable lactone-based elastomers that can be used in continuous digital light processing 3D printing applications

Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 21% predicted to occur until 2027. Medical and dental products account for the…

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A synergistic chemotherapy and radiotherapy drug delivery technology for treating prostate cancer tumors

A synergistic chemotherapy and radiotherapy drug delivery technology for treating prostate cancer tumors

Unmet Need Pancreatic cancer is one of the deadliest manifestations of cancer in clinical oncology. Despite accounting for only 3.2% of all cancer cases, it is the third leading cause of cancer-related mortality. National Comprehensive…

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A low-cost and effective ethanol ablation tumor treatment

A low-cost and effective ethanol ablation tumor treatment

Unmet Need Cervical cancer is the fourth most common cancer among woman globally, with an estimated 342,000 deaths in 2020, of which 90% of deaths occurred in low-and middle-income countries. A primary reason for this…

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Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors

Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors

Unmet Need Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL, CD253) acts as an activator of apoptosis in many tumor cells, while remaining innocuous to normal cells. Both membrane-bound and soluble forms of TRAIL can trigger apoptosis…

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Use of sustained-release 5-hydroxytrypophan in treating constipation

Use of sustained-release 5-hydroxytrypophan in treating constipation

Unmet Need Over 10% of the population suffers from constipation disorders, with irritable bowel syndrome-constipation and chronic idiopathic constipation being the most prevalent diagnoses. Current treatment options for constipation are available over-the-counter by prescription. However,…

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Flexible needle for targeted delivery of chronic pain treatment

Flexible needle for targeted delivery of chronic pain treatment

Unmet Need For patients suffering from chronic pain associated with degenerative changes, inflammation, neuropathy or cancer, the ability to carry out daily life and work activities is a challenge. Current treatment methods are limited and…

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Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy

Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy

Unmet Need In the United States alone, over 1.8 million new patients were diagnosed with cancer in 2021, and over 600,000 patients died from the disease. Cytostatic nucleotides, such as gemcitabine and 5-fluorouracil, have been…

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Method to trap and transport small particles with acoustic forces

Method to trap and transport small particles with acoustic forces

Value Proposition Acoustic tweezers use ultrasound to create radiation force potential wells that enable precise and contact-free manipulation of physical and biological objects across a broad object size range. It is a fast-developing platform that…

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A stable, easily manufactured intranasal oxytocin formulation that contains only food grade preservatives

A stable, easily manufactured intranasal oxytocin formulation that contains only food grade preservatives

Unmet Need Current formulations of oxytocin used for the treatment of neuropsychiatric disorders have several drawbacks. For example, many intravenous and intranasal formulations, like those approved in Europe, contain preservatives like chlorobutanol which is highly…

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A class of biodegradable stealth polymers to improve drug delivery

A class of biodegradable stealth polymers to improve drug delivery

Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…

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An injectable hydrogel scaffold that delivers gene therapies locally

An injectable hydrogel scaffold that delivers gene therapies locally

Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…

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A tumor-targeting delivery method for chemotherapeutics and other cargo

A tumor-targeting delivery method for chemotherapeutics and other cargo

Unmet Need Delivery and therapeutic efficacy of small molecule imaging agents and chemotherapeutics are hampered by their short half-life, low solubility, non-selectivity to cancer cells, and toxic side effects. Small molecule chemotherapeutics, although in routine…

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