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A class of biodegradable stealth polymers to improve drug delivery

A class of biodegradable stealth polymers to improve drug delivery

Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…

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An injectable hydrogel scaffold that delivers gene therapies locally

An injectable hydrogel scaffold that delivers gene therapies locally

Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…

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A tumor-targeting delivery method for chemotherapeutics and other cargo

A tumor-targeting delivery method for chemotherapeutics and other cargo

Unmet Need Delivery and therapeutic efficacy of small molecule imaging agents and chemotherapeutics are hampered by their short half-life, low solubility, non-selectivity to cancer cells, and toxic side effects. Small molecule chemotherapeutics, although in routine…

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A nanoparticle drug delivery system for small molecule cancer drugs that binds endogenous albumin

A nanoparticle drug delivery system for small molecule cancer drugs that binds endogenous albumin

Unmet Need Small molecule cancer drugs often suffer from poor systemic exposure, resulting from their low water solubility and short plasma half-life. Additionally, the off-target toxicity is the main challenge that undermines efficacy. Nanoparticle drug…

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A rod-like nanoparticle drug delivery system for hydrophilic small molecules

A rod-like nanoparticle drug delivery system for hydrophilic small molecules

Unmet Need New strategies to load small molecule drugs into nanoparticles are a powerful approach to improve the therapeutic efficacy of chemotherapeutics, and this has been a successful strategy for overcoming the limitations of poor…

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A novel class of nanoparticles that can be recombinantly synthesized for drug delivery and other applications

A novel class of nanoparticles that can be recombinantly synthesized for drug delivery and other applications

Unmet Need Recombinant biopolymers are used for a diverse array of applications including drug delivery, tissue engineering, and clinical diagnostics. Peptide polymers are particularly attractive candidates for biomedical applications because of their biocompatibility, biodegradability, and…

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Thermally-responsive elastin-like peptides for improving the efficacy of anticancer agents

Thermally-responsive elastin-like peptides for improving the efficacy of anticancer agents

Unmet Need The goal of chemotherapy is to deliver an anticancer agent, typically a small molecule, at a high dose to a tumor to kill rapidly proliferating tumor cells. Unfortunately, the maximum dose of many…

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Genetically encoded hybrid biomaterials that are thermally responsive and tunable

Genetically encoded hybrid biomaterials that are thermally responsive and tunable

Unmet Need Developing new biomaterials is an active area of research, with applications in tissue engineering, regenerative medicine, and drug-delivery. In particular, protein- and peptide-based materials are attractive candidates for these applications because of their…

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Inactivating viral replication with CRISPR/Cas systems

Inactivating viral replication with CRISPR/Cas systems

Value Proposition Current gene therapy approaches based upon targeted DNA endoculeases, such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), are based upon custom built DNA binding domains. Although gene therapy with…

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Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity

Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity

Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…

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Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions

Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions

Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…

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Improving osteoarthritis treatment through facilitated transport of bisphosphonates to chondrocytes by vitamin C

Improving osteoarthritis treatment through facilitated transport of bisphosphonates to chondrocytes by vitamin C

Value Proposition Osteoarthritis is the most prevalent of all forms of arthritis and the second greatest cause of disability worldwide. The Centers for Disease Control and Prevention estimates that osteoarthritis affects over 30 million adults…

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