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New small molecules targeting castration-resistant prostate cancer

New small molecules targeting castration-resistant prostate cancer

Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…

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Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…

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Diagnostic and treatment for chronic and acute phase myeloid leukemia

Diagnostic and treatment for chronic and acute phase myeloid leukemia

Value Proposition While cancer therapies have increased survival for many tumor types, the reality is that 50-60% of cancer patients will die from the disease. This highlights a need for the continued search for targeted…

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SUMO as a marker of cancer development and target for cancer therapy

SUMO as a marker of cancer development and target for cancer therapy

Value Proposition Cancer therapy remains challenging, and the production of new inhibitor therapies is stinted by the need for clear successful targets that will block tumor cell proliferation. Small ubiquitin-like modifier (SUMO) proteins and the…

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