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3D cavitation mapping to improve laser lithotripsy for the treatment of kidney stones
Unmet Need The prevalence of kidney stones is on the rise, having increased from approximately 4% in the 1970s to nearly 10% today. Approximately 1 in 10 of Americans will experience a kidney stone in…
Non-invasive peripheral retinal scanner using OCT
Unmet Need Images and light that sporadically appear in an individual’s visual field are known as “Flashes and floaters.” These optical aberrations bring approximately 150,000 patients in for eye exams each year in the United…
Multiscale coherence imaging for assessing epithelial tissue health in precancerous detection
Unmet Need Epithelial cells act as the body’s first line of defense against foreign elements and are constantly being replaced by newly grown cells. Due in part to these factors, 90% of all cancers originate…
A quality control tool for multi-energy X-ray computed tomography imaging
Unmet Need X-ray computed tomography (CT) imaging devices are ubiquitous in any radiology department and CT examinations are among the most commonly ordered diagnostic procedure. Multi-energy computed tomography is an emerging imaging technology that is…
Optical device for in vivo assessment of tissues
Value Proposition Fluorescence and diffuse reflectance spectroscopy in the ultraviolet-visible (UV-VIS) spectrum are increasingly being investigated for tissue characterization. These biological scatterers, absorbers, and fluorophores may be used to indicate the existence of certain diseases.…
A computational algorithm-based method for extracting intrinsic fluorescence properties of tissue
Value Proposition Fluorescence spectroscopy has been used successfully to discriminate premalignancy and malignancy in a number of organ sites. However, due to the complex interplay of absorption, scattering, and fluorescence in tissue, it is difficult…
Fiber optic probes with self-calibration capability for tissue optical spectroscopy
Value Proposition UV-visible (UV-VIS) diffuse reflectance spectroscopy (DRS) is sensitive to the absorption and scattering properties of biological molecules in tissue and thus can be used as a noninvasive in vivo tool to obtain quantitative…
TARGET: Tunable and Amplified Raman Gold Nanoprobes for Effective Tracking
Unmet Need Surface-enhanced Raman scattering (SERS) has led to the development of important biomedical analysis and sensing tools ranging from in vitro diagnostics to in vivo imaging through SERS nanoprobes. However, these nanoprobes have limited…
Black blood delayed enhancement magnetic resonance imaging
Technnology Duke University is seeking a corporate partners to commercialize a method of improved detection of infarcted heart tissue. The technology provides a dark blood delayed enhancement technique that improves the visualization of subendocardial infarcts…