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3D cavitation mapping to improve laser lithotripsy for the treatment of kidney stones
Unmet Need The prevalence of kidney stones is on the rise, having increased from approximately 4% in the 1970s to nearly 10% today. Approximately 1 in 10 of Americans will experience a kidney stone in…
Acoustofluidic technologies for precision control in microfluidic systems
Unmet Need Achieving precise manipulation of particles, cells, and droplets in microscale liquid systems is a major challenge in life sciences, material sciences, and chemistry. Traditional microfluidic systems, which use hydrophobic channels and pressure differentials…
Method to trap and transport small particles with acoustic forces
Value Proposition Acoustic tweezers use ultrasound to create radiation force potential wells that enable precise and contact-free manipulation of physical and biological objects across a broad object size range. It is a fast-developing platform that…
Surface acoustic wave based separation techniques
Value Proposition Complex biofluids such as blood, urine etc. contain a plethora of particles of interest that are of diagnostic and research interest. Examples of such particles may include exosomes, or Circulating Tumor Cells (CTC).…
Fiber optic probes with self-calibration capability for tissue optical spectroscopy
Value Proposition UV-visible (UV-VIS) diffuse reflectance spectroscopy (DRS) is sensitive to the absorption and scattering properties of biological molecules in tissue and thus can be used as a noninvasive in vivo tool to obtain quantitative…
A method for detecting RNA and DNA using surface-enhanced Raman scattering (SERS)
Unmet Need The development of practical and sensitive techniques for screening nucleic acid biomarkers related to medical diseases and cancers is critical for early diagnosis, prevention, and effective interventions. Recent advances in molecular profiling technology…
Integrated thin film silicon detectors for fluorescence sensing
Unmet Need Microfluidic chip-based systems allow for rapid and sensitive biochemical analyses of very small sample quantities. Due to the prevalence of optical equipment in laboratories, optical detection has become the most popular method for…