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Structural variants of TERT in brain tumors

Structural variants of TERT in brain tumors

Unmet Need Glioblastoma is the most common type of malignant brain tumor, and accounts for 47.7% of all brain cancer cases. Despite aggressive treatment, the median overall survival for glioblastoma is 15 to 18 months.…

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Reagentless biosensors to detect multiple analytes

Reagentless biosensors to detect multiple analytes

Unmet Need Although biosensors are in widespread use to detect and report analytes, such as the level of nutrients in food and beverage samples, blood glucose in patients, and contamination in water samples, many suffer…

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A simple blood test that can predict heart failure earlier than current methods

A simple blood test that can predict heart failure earlier than current methods

Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…

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A humanized pro-N-cadherin antibody that can be used for treating and predicting heart failure

A humanized pro-N-cadherin antibody that can be used for treating and predicting heart failure

Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…

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A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy

A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy

Unmet Need Cancer immunotherapy provides great advantages over traditional cytotoxic chemotherapy and radiation with more durable clinical outcomes and an improved quality of life. The number of US patients eligible for immunotherapy was estimated to…

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Breast cancer risk prediction technology using genomic classifier

Breast cancer risk prediction technology using genomic classifier

Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…

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A smartphone-based detector for mobile health applications

A smartphone-based detector for mobile health applications

Unmet Need It is estimated that there are over 6 billion smartphone users worldwide, which translates to almost 83% of the world’s population. Due to their widespread use, smartphones present a golden opportunity to redefine…

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All dielectric absorber for improved real-time imaging in the terahertz spectrum

All dielectric absorber for improved real-time imaging in the terahertz spectrum

Value Proposition Discoveries over the past decades have unveiled unique characteristics of the far-infrared or terahertz (THz) spectrum spanning from 0.3 THz to 10 THz, including non-ionization of biological materials, easy penetration into dielectric and…

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A genomics-based method to identify cancer patients that will benefit from immune checkpoint therapy

A genomics-based method to identify cancer patients that will benefit from immune checkpoint therapy

Unmet Need Non-small-cell lung cancer accounts for 82% of all lung cancer diagnoses. Immune checkpoint blockade treatment is an exciting new course of action among advanced stage non-small-cell lung cancer patients. However, only a minority…

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Bio Layer Interferometry Probe (BLIP) for in-vivo analyte detection

Bio Layer Interferometry Probe (BLIP) for in-vivo analyte detection

Unmet Need Diagnostic tests play a critical role in the clinical diagnosis, management, and monitoring of disease. These tests are designed to analyze biological specimens to identify analytes of interest by employing highly specific and…

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Genomic Biomarkers of Locally Advanced Breast Cancer (LABC) and Inflammatory Breast Cancer (IBC)

Genomic Biomarkers of Locally Advanced Breast Cancer (LABC) and Inflammatory Breast Cancer (IBC)

Unmet Need Locally advanced breast cancer (LABC) and inflammatory breast cancer (IBC) are associated with high 5-year mortality rates (respectively 55% and 33%), especially when compared to early-stage breast cancers (~80%). LABC and IBC are…

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Rapid molecular screening test for the diagnosis of radiation exposure

Rapid molecular screening test for the diagnosis of radiation exposure

Unmet Need The threat of terrorism via detonation of radiological weapons or improvised nuclear devices remains a major public health and national security concern. Victims exposed to high doses of ionizing radiation develop acute radiation…

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