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A therapeutic target to prevent or treat castration-resistant prostate cancer
Unmet Need Prostate cancer is the second leading cause of cancer death in American men. Androgen deprivation therapy has been the standard of care for initial management of advanced prostate cancer, but resistance to therapy…
Optical device for in vivo assessment of tissues
Value Proposition Fluorescence and diffuse reflectance spectroscopy in the ultraviolet-visible (UV-VIS) spectrum are increasingly being investigated for tissue characterization. These biological scatterers, absorbers, and fluorophores may be used to indicate the existence of certain diseases.…
A computational algorithm-based method for extracting intrinsic fluorescence properties of tissue
Value Proposition Fluorescence spectroscopy has been used successfully to discriminate premalignancy and malignancy in a number of organ sites. However, due to the complex interplay of absorption, scattering, and fluorescence in tissue, it is difficult…
Fiber optic probes with self-calibration capability for tissue optical spectroscopy
Value Proposition UV-visible (UV-VIS) diffuse reflectance spectroscopy (DRS) is sensitive to the absorption and scattering properties of biological molecules in tissue and thus can be used as a noninvasive in vivo tool to obtain quantitative…
Gene signature for prediction of acute rejection in kidney transplant
Unmet Need Kidney transplant is the best current treatment for kidney failure. The kidney is the most common organ to be transplanted, and in 2019 there were 23,405 kidney transplants in the United States. Unfortunately,…
Algorithm for improving the clarity of electrocardiograms for patients with LVADs
Unmet Need Electrocardiogram (ECG) measurements are an important tool for monitoring patient heart health and can detect issues related to arrythmias, heart attacks, and cardiomyopathy. Heart health is especially important to monitor in patients who…
TARGET: Tunable and Amplified Raman Gold Nanoprobes for Effective Tracking
Unmet Need Surface-enhanced Raman scattering (SERS) has led to the development of important biomedical analysis and sensing tools ranging from in vitro diagnostics to in vivo imaging through SERS nanoprobes. However, these nanoprobes have limited…
A method for detecting RNA and DNA using surface-enhanced Raman scattering (SERS)
Unmet Need The development of practical and sensitive techniques for screening nucleic acid biomarkers related to medical diseases and cancers is critical for early diagnosis, prevention, and effective interventions. Recent advances in molecular profiling technology…
Genomic predictors of mortality following heart surgery
Unmet Need Several models have been developed to estimate the risk of mortality following cardiac surgery, including the European System for Cardiac Operative Risk Evaluation (EuroSCORE), but they all are limited in their ability to…
Metabolite biomarkers of human heart failure
Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…
A platform for detecting and discriminating odorant molecules in the vapor phase
Unmet Need Mammals are capable of detecting and recognizing a large number of odors. Olfactory receptors (ORs) play a crucial role in detecting and recognizing odorant molecules. There has been growing interest in elucidating the…
Integrated thin film silicon detectors for fluorescence sensing
Unmet Need Microfluidic chip-based systems allow for rapid and sensitive biochemical analyses of very small sample quantities. Due to the prevalence of optical equipment in laboratories, optical detection has become the most popular method for…