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Illuminated medical tubing for safer line management
Unmet Need Several clinical care scenarios require the use of multiple devices attached to patients to monitor their well-being. These devices can include pulse oximeter, electrocardiogram, IV lines, in addition to other equipment essential for…
CRISPR-based antiviral treatment of coronavirus infections
Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…
Small molecules that target RNA structures within the CoV genome
Unmet Need SARS-CoV-2 is the etiological agent of the COVID-19 respiratory disease, the largest scale respiratory virus pandemic the world has witnessed since the 1918 Spanish flu and that has claimed more than 1.4 million…
Platform for generating a seasonal vaccine for both influenza and coronaviruses
Unmet Need Similar to the flu vaccine, the need for seasonal post-immunization boosting to offer protection following COVID-19 vaccines remains possible. However, more than 8 percent of people who received a first dose of Pfizer…
A device to improve the diagnostic success of thoracentesis procedures: PulmoPivot
Unmet Need The buildup of fluid in the chest cavity, called pleural effusion, that occurs in 1.5 million people in the U.S. every year is usually benign. However, it can also be the first indication…
Intubation tent to protect healthcare workers from infected patients
Value Proposition Under the current COVID crisis, health care workers need protection against respiratory infections transmitted by patients undergoing treatment. Patients undergoing intubation for surgery or prior to being placed on a ventilator can expose…
Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury
Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…
Fluorescence-based high-throughput assay for identifying antivirals to control COVID-19 pandemic
Unmet Need Current efforts to control COVID-19 are largely focused on behavioral modifications such as social distancing and the use of masks. These approaches attempt to slow the spread of the virus, but meaningful control…
Novel small molecule mast cell activator vaccine adjuvants
Value Proposition Mast cells (MCs) are innate immune cells highly prevalent in the dermal region of the skin and in the respiratory, gastrointestinal, and urinary tract mucosa. The strategic location at the host–environment interface and…
Molecular diagnostic test for acute respiratory viral infections
Unmet Need Acute respiratory viral (ARV) infections are among the most common reasons for patient visits in primary and acute care settings. ARV can be caused by many viruses including human rhinovirus (HRV), respiratory syncytial…
Sublingual immunization using supramolecular peptide-polymer conjugate tablets
Value proposition Immunization with vaccines prevent illness, disability, and currently avert an estimated 2 to 3 million deaths every year. However, commonly-used vaccine technology platforms can be unpredictable, require a high manufacturing cost, and often…
Device for personalizing ventilation settings on a shared system
Value Proposition In times of emergency, multiple patients might require to be supported on the same ventilator system. However, patients might have different degrees of lung function, including lung compliance and required volumes of support.…