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TGF-β1-Secreting Bone Marrow Stromal Cell Therapy for Long-Lasting Neuropathic Pain Relief

TGF-β1-Secreting Bone Marrow Stromal Cell Therapy for Long-Lasting Neuropathic Pain Relief

Unmet Need Neuropathic pain remains a significant clinical challenge, with current treatments providing only temporary relief and failing to address the underlying neuroinflammatory mechanisms. Chronic nerve injury leads to persistent pain hypersensitivity, which is difficult…

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Novel epigenome editors for multiplexed gene regulation

Novel epigenome editors for multiplexed gene regulation

Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…

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Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis

Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis

Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…

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Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development

Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development

Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…

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Stem cell-derived factors for treating pathologic conditions

Stem cell-derived factors for treating pathologic conditions

1.3 million Americans experience a heart attack (acute myocardial infarction or AMI) each year. A significant percentage of these patients die from restricted blood flow to the heart (ischemia) and significant loss of cardiac function.…

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