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New small molecules targeting castration-resistant prostate cancer
Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…
Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…
LpxH targeting antibiotics for Gram-negative bacteria
Unmet Need Antimicrobial resistance of bacteria to antibiotics is a major threat to public health. In 2019, 4.95 million deaths, 64% of all bacterial infection related deaths globally, were attributed to antimicrobial resistance to antibiotics.…
Non-opioid treatment for chronic pain using a neurotensin receptor 1 modulator
Unmet Need For individuals experiencing chronic pain, day-to-day tasks and activities can become difficult or impossible. It can also lead to other long-term health challenges including insomnia, stress, anxiety, and depression. Chronic pain is so…
Use of rifaximin and bacterial strains for treating probable neurodegenerative disorders like Alzheimer’s Disease
Unmet Need There is an urgent need to develop novel therapies for neurodegenerative diseases and conditions such as Alzheimer's disease (AD). Ten percent of people over age 65 and up to 50% over age 85…
Topical PHD inhibitors to enhance wound healing by reducing ischemia
Unmet Need Millions of patients experience unhealed skin wounds, and with the rise in number of surgeries per year along with the increase in older population, this burden is expected to increase. One aspect of…
Endocrine cancer treatment method using glycerate
Unmet Need Endocrine cancers, those that affect organs that secrete hormones, are among the most common cancers in the U.S. Tumors that form in the organs of the endocrine system often secrete excess hormones or…
Topical MEK inhibition as a new modality for inflammatory skin diseases and cancers
Unmet Need Inflammatory skin conditions affect many people, with a wide range of severities. Common skin disorders, such as psoriasis and atopic dermatitis, affect close to 20% of the population. Skin lesions associated with bone…
Method to sensitize cancer radiotherapy and chemotherapy
Unmet Need While radiotherapy and/or chemotherapy are used for >90% of cancer patients in clinical settings, the therapeutic outcomes are far from ideal for many types of tumors due to the development of drug resistance…
Melanoma treatment method using estrogen modulating small molecules
Unmet Need Metastatic melanoma, skin cancer that has spread, is an incredibly deadly cancer, with a median survivorship of 6-9 months. For patients with melanoma, a frequently used therapy is immune checkpoint blockade (ICB). These…
A process to selectively access allylic diamines that can aid in identifying new drug compounds
Unmet Need When developing new drugs, researchers often rely on naturally occurring compounds to learn what design features illicit a biological response that can be tailored for treating a given disease or ailment. However, reproducing…
A method of treating and preventing gastrointestinal disorders
Unmet Need Gastrointestinal disorders such as inflammatory bowel disease, constipation, and intestinal pseudo-obstruction have been estimated to affect more than 40% of adults worldwide. These disorders are often associated with alterations in gut microbiota, which…