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Transgenic zebrafish to direct epicardial gene expression

Transgenic zebrafish to direct epicardial gene expression

Technology Duke inventors have generated a novel zebrafish model that allows researchers to study epicardial cells during embryonic heart development and myocardial regeneration. This zebrafish line is termed Tg(tcf21:CreER)pd42. Specifically, this transgenic model was created…

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Olfactory neuroblastoma mouse model

Olfactory neuroblastoma mouse model

Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…

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Mouse model of Alzheimer’s disease

Mouse model of Alzheimer’s disease

Unmet Need Alzheimer’s disease is a neurodegenerative disease marked by loss of cognitive function. There is currently no cure for Alzheimer’s disease. In fact, the limited therapies available only alleviate symptoms for a short time…

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Use of sustained-release 5-hydroxytrypophan in treating constipation

Use of sustained-release 5-hydroxytrypophan in treating constipation

Unmet Need Over 10% of the population suffers from constipation disorders, with irritable bowel syndrome-constipation and chronic idiopathic constipation being the most prevalent diagnoses. Current treatment options for constipation are available over-the-counter by prescription. However,…

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Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment

Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment

Value Proposition Defects in acetylcholine transmission have been associated with several major neurodegenerative disorders including Alzheimer’s disease, dementia, cerebral palsy, Parkinson’s disease, Huntington’s disease and myasthenia gravis. Although cholinergic dysfunction has been implicated in these…

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Shank3 knockout mice as a model for autism

Shank3 knockout mice as a model for autism

The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated…

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