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A predictive model for early detection of psychiatric risk in adolescents
Unmet Need According to the World Health Organization, nearly 15% of adolescents (10 to 19-year-olds) experience a mental health condition, many of which remain undiagnosed and untreated. Since the beginning of the COVID-19 pandemic, the…
A simple blood test that can predict heart failure earlier than current methods
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…
Morphological multiparameter filtration and persistent homology in mitochondrial image analysis
Unmet Need Current mitochondrial network analysis tools require significant manual intervention, making them labor-intensive, subjective, and prone to variability. These limitations hinder the reproducibility and accuracy needed for studying complex mitochondrial morphologies in disease diagnostics,…
3D cavitation mapping to improve laser lithotripsy for the treatment of kidney stones
Unmet Need The prevalence of kidney stones is on the rise, having increased from approximately 4% in the 1970s to nearly 10% today. Approximately 1 in 10 of Americans will experience a kidney stone in…
Acoustofluidic technologies for precision control in microfluidic systems
Unmet Need Achieving precise manipulation of particles, cells, and droplets in microscale liquid systems is a major challenge in life sciences, material sciences, and chemistry. Traditional microfluidic systems, which use hydrophobic channels and pressure differentials…
Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis
Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…
Molecular Classifiers of Bacterial Infection
Unmet Need Bacterial infections can lead to various outcomes, with septicemia posing significant morbidity and mortality risks for patients. Septicemia occurs when bacteria enter and spread through the bloodstream, triggering an extreme immune response in…
Gene expression signature to predict sepsis mortality
Unmet Need Sepsis is responsible for half of the in-hospital deaths in the US. It is characterized by organ dysfunction resulting from an uncontrolled response to an infection. The standard treatment for sepsis includes source…
Gene signature for prediction of acute rejection in kidney transplant
Unmet Need Kidney transplant is the best current treatment for kidney failure. The kidney is the most common organ to be transplanted, and in 2019 there were 23,405 kidney transplants in the United States. Unfortunately,…
ClinVar: Determining the factors influencing cardiomyopathy-associated gene variant call evolution
Description ClinVar is a freely accessible, public archive of reports of human variations classified for diseases and drug responses, with supporting evidence. ClinVar thus facilitates access to and communication about the relationships asserted between human…
Non-invasive peripheral retinal scanner using OCT
Unmet Need Images and light that sporadically appear in an individual’s visual field are known as “Flashes and floaters.” These optical aberrations bring approximately 150,000 patients in for eye exams each year in the United…
Metabolite biomarkers of human heart failure
Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…