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HIV treatment and prevention using broadly neutralizing antibodies

HIV treatment and prevention using broadly neutralizing antibodies

Unmet Need For over 40 years, the HIV pandemic has affected millions, reducing life expectancy and quality of life. As of 2021, 38.4 million people globally are living with HIV, with about 1.5 million new…

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Gene expression signature to predict sepsis mortality

Gene expression signature to predict sepsis mortality

Unmet Need Sepsis is responsible for half of the in-hospital deaths in the US. It is characterized by organ dysfunction resulting from an uncontrolled response to an infection. The standard treatment for sepsis includes source…

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Molecular Classifiers of Bacterial Infection

Molecular Classifiers of Bacterial Infection

Unmet Need Bacterial infections can lead to various outcomes, with septicemia posing significant morbidity and mortality risks for patients. Septicemia occurs when bacteria enter and spread through the bloodstream, triggering an extreme immune response in…

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Identification and application of novel lipoglycodepsipeptide antibiotics

Identification and application of novel lipoglycodepsipeptide antibiotics

Unmet Need Antibiotic resistance (ABR) is a global public health concern. In 2019, an estimated five million deaths were attributed to antibiotic resistant pathogens. A recent study estimates that ABR could cause nearly ten million…

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FK520 analogs modified to increase fungal specificity with applications in antifungal therapy

FK520 analogs modified to increase fungal specificity with applications in antifungal therapy

Unmet Need Fungal infections are becoming more prevalent worldwide, with 150 million cases and 1.7 million fatalities reported in the last year alone. These are largely caused by multi-drug-resistant fungi, which makes treatment more challenging.…

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Novel necroptosis inhibitor for treating inflammatory diseases

Novel necroptosis inhibitor for treating inflammatory diseases

Unmet Need Necroptosis is a form of cell death characterized by the rapid loss of plasma membrane integrity, leading to the activation of the immune system and subsequent inflammation. This process has been implicated in…

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Universal Antibodies Effective Against Both Influenza A and B

Universal Antibodies Effective Against Both Influenza A and B

Unmet Need Distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing significant widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV and IBV hemagglutinins (HAs) could protect against…

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MEWS: a clinical model to predict probability of maternal sepsis trigger in obstetrics patients

MEWS: a clinical model to predict probability of maternal sepsis trigger in obstetrics patients

Unmet Need Sepsis is a life-threatening emergency characterized by an overactive and improper inflammatory response by the body to an infection or injury leading to tissue damage, organ failure and death if not treated promptly.…

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LpxH targeting antibiotics for Gram-negative bacteria

LpxH targeting antibiotics for Gram-negative bacteria

Unmet Need Antimicrobial resistance of bacteria to antibiotics is a major threat to public health. In 2019, 4.95 million deaths, 64% of all bacterial infection related deaths globally, were attributed to antimicrobial resistance to antibiotics.…

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Smart microscope for diagnosing disease

Smart microscope for diagnosing disease

Value Proposition Since its invention, the microscope has been optimized for interpretation by a human observer. Recently, however, deep learning algorithms have been developed for automated image analysis in a variety of important contexts, such…

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CRISPR-based antiviral treatment of coronavirus infections

CRISPR-based antiviral treatment of coronavirus infections

Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…

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Wearable device for early detection of influenza and common cold

Wearable device for early detection of influenza and common cold

Unmet Need Approximately 10% of the US population is infected with influenza each year resulting in 3 to 5 million severe cases and up to 500,000 deaths. Early detection of influenza-like illness can limit the…

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