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WireCleat – Fully safe Seldinger Technique device for prevention of guide wire retention
Unmet Need Catheters are widely used in many medical disciplines as a means of gaining easy access to internal body cavities like blood vessels or hollow organs. The Seldinger technique is a common method for…
A simple blood test that can predict heart failure earlier than current methods
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…
A humanized pro-N-cadherin antibody that can be used for treating and predicting heart failure
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…
Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis
Unmet Need Driven by the rising tide of obesity and lack of medical treatment, it is estimated that 1 out of 4 adults in the US has non-alcoholic fatty liver disease or non-alcoholic steatohepatitis (NAFLD/NASH).…
A device for clinical wet-to-wet connections that alleviates healthcare provider anxiety and enhances patient quality of care
Unmet Need Extracorporeal membrane oxygenation (ECMO) is a rapidly growing method of providing life-saving support to a patient suffering from heart or lung failure. Between 2010 and 2021 ECMO runs in the United States grew…
Transcatheter device for restricting blood flow through the pulmonary artery
Unmet Need In the United States, approximately 10,000 newborns a year will require surgery for a congenital heart defect such as atrial or ventricular septal defects. These defects can cause excessive blood flow to the…
Blood pressure control by gene editing
Unmet Need The World Health Organization estimates that high blood pressure (hypertension) results in approximately 9 million annual deaths worldwide. Currently available drugs used to control blood pressure can be effective but are limited by…
Rapid application of portable tourniquet for use in junctional regions
Unmet Need There is a need for easy to use, efficient and cost-effective tourniquets for hard to isolate areas such as junctional regions of the body, areas that are not suitable for application of circumferential…
A novel acoustic biomarker for quality of life in LVAD recipients
Unmet Need Left ventricular devices (LVADs) are surgically implanted pumps that improve survival in patients with advanced heart failure. According to St. Judes, in the U.S. in 2016, over 7% of LVAD users reported poor…
A signal processing algorithm to mitigate LVAD noise in sound recording of LVAD recipients
Unmet Need Left ventricular devices (LVADs) are surgically implanted pumps that improve survival in patients with advanced heart failure. While lifesaving, LVAD therapy is also associated with high morbidity, in part due to difficulties identifying…
Aptamer anticoagulant therapy to reduce complications of ECMO treatment
Unmet Need Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for critically ill patients with low oxygen levels. During ECMO, the patient’s blood flows through an external oxygenation device. This requires co-treatment with an anticoagulant…
Near-infrared fluorescent proteins for live cell and animal imaging
Unmet Need Fluorescent microscopy is one of the most common research tools used by biologists and has a global market value expected to exceed $768 million by 2023. Many of the currently available fluorescent protein…