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Muscle-targeted gene therapy for SLC25A4 mitochondrial deficiency

Muscle-targeted gene therapy for SLC25A4 mitochondrial deficiency

Unmet Need There is a significant unmet need for disease-modifying therapies that address mitochondrial dysfunction in inherited cardiomyopathies and myopathies such as SLC25A4 deficiency. Existing treatments are limited to supportive care and heart transplantation, with…

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Permanent blood pressure control through liver-directed gene editing

Permanent blood pressure control through liver-directed gene editing

Unmet Need The World Health Organization estimates that high blood pressure (hypertension) results in approximately 9 million annual deaths worldwide. While current medications can lower blood pressure, they are limited by the need for lifelong…

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Novel TRPV4-Targeted Therapy for Arrhythmic Cardiomyopathy

Novel TRPV4-Targeted Therapy for Arrhythmic Cardiomyopathy

Unmet Need Arrhythmic cardiomyopathy (ACM) is a life-threatening condition characterized by fatty-fibrotic remodeling of the heart muscle, leading to arrhythmias, heart failure, and sudden cardiac death. While 60% of ACM cases are linked to known…

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Precision Engineering of Neural Circuits via Designer Connexins for Long-Term Cellular Integration

Precision Engineering of Neural Circuits via Designer Connexins for Long-Term Cellular Integration

Unmet Need Gap junctions are crucial for enabling the direct flow of ions and small molecules between cells, playing a significant role in synchronizing electrical activity in organs like the heart and brain. However, mutations…

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A simple blood test that can predict heart failure earlier than current methods

A simple blood test that can predict heart failure earlier than current methods

Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…

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Targeted delivery of gene therapy via exosomes for cardiomyocyte reprogramming

Targeted delivery of gene therapy via exosomes for cardiomyocyte reprogramming

Unmet Need Every year, close to 1 million Americans experience a heart attack. A heart attack results in the loss of specialized cells called cardiomyocytes, which are crucial for the heart’s contraction and rhythmic beating.…

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Dark-Blood Delayed-Enhancement MRI: Improved Tissue Contrast and Blood-Pool Signal Suppression

Dark-Blood Delayed-Enhancement MRI: Improved Tissue Contrast and Blood-Pool Signal Suppression

Unmet Need Delayed-enhancement MRI (DE-MRI) is the standard for imaging myocardial infarction (MI), providing high-resolution maps of infarcted and viable myocardium. However, DE-MRI often suffers from poor differentiation between infarcted myocardium and the bright left…

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ClinVar: Determining the factors influencing cardiomyopathy-associated gene variant call evolution

ClinVar: Determining the factors influencing cardiomyopathy-associated gene variant call evolution

Description ClinVar is a freely accessible, public archive of reports of human variations classified for diseases and drug responses, with supporting evidence. ClinVar thus facilitates access to and communication about the relationships asserted between human…

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Central Venous Catheter Insertion Device

Central Venous Catheter Insertion Device

Unmet Need Central Venous Catheterization (CVC) is a common procedure where a catheter is inserted into a large vein, typically in the neck, chest, or groin. With 5 million insertions a year, representing 8% of…

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Metabolite biomarkers of human heart failure

Metabolite biomarkers of human heart failure

Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…

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Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…

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Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…

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