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SUMOylation as a therapeutic target in inflammatory bowel diseases and sepsis
Unmet Need Inflammatory Bowel Disease (IBD) affects between 2.4 – 3.1 million people in the USA alone, with significant risks of complications such as sepsis. Chronic inflammation from IBD results in severe intestinal tissue damage,…
Chemical modulators of immune checkpoints and cell growth for cancer treatment
Unmet Need Each year there are over 1.6 million new cases of cancer in the US, and over 600,000 cases prove fatal. Treating various types of cancer can be particularly challenging because of the complex…
A method of treating and preventing gastrointestinal disorders
Unmet Need Gastrointestinal disorders such as inflammatory bowel disease, constipation, and intestinal pseudo-obstruction have been estimated to affect more than 40% of adults worldwide. These disorders are often associated with alterations in gut microbiota, which…
A machine learning model to assess colorectal cancer risk using whole blood samples
Unmet Need Colorectal cancer is the third most commonly occurring cancer in men and the second in women. Early detection and treatment have contributed to an overall dropping of the death rate for several decades,…