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Small molecule inhibitors of eHSP90 to treat autoimmune diseases
Unmet Need It is estimated that autoimmune diseases affect 1 out of every 10 individuals. These debilitating diseases are the result of the immune system inappropriately targeting and attacking the body. The resulting disease is…
T-cell releasing antibody for breast cancer tumor metastasis prevention
Unmet Need Metastatic breast cancer is a deadly form of breast cancer with only 1/3 of patients diagnosed with it living to 5 years post-diagnosis. Metastasis can occur either at disease onset (6% of patients)…
Wearable smart radiation reporting material
Unmet Need Excess radiation exposure can result in DNA damage and tissue injury. Individuals who are occupationally exposed to ionizing radiation need to monitor and track radiation exposures. Small, personal radiation dosimeters currently exist, but…
A drug-infused hydrogel implant for glaucoma drainage devices
Unmet Need Glaucoma is an ocular disease involving heightened eye pressure most commonly leading to blindness, affecting roughly 3 million Americans. Current treatments include anti-steroidal or anti-inflammatory drugs to remove excess ocular fluid or decrease…
Leukocyte phenotyping methods to provide prognostic information and risk/resilience stratification for surgical procedures and critical illness
Unmet Need It is estimated that surgical complications arise in 16.4%, or almost 1 in 6 surgical procedures in the United States. Most complications have an immunological basis related to infection or aberrant adaptation to…
A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction
Unmet Need The number of Americans with addiction-related disorders, including substance use disorders (SUD) and food addiction is increasing rapidly each year. Recent estimates indicate that >20 million people in the U.S. have been diagnosed…
Connecting cardiac and respiratory 3DCT imaging for 5DCT heart motion management
Unmet Need Ventricular tachycardia (VT) is a primary condition of heart disease noted as an irregularity of heart rhythm due to improper electrical signaling in the ventricles that causes an abnormally high heart rate. VT…
Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…
Anesthesiology Resource Management System (ARMS), an AI software to predict and plan resource utilization
Unmet Need Surgery makes up a majority of both the costs and revenue for major hospitals, with operating rooms accounting for 40% of an average hospital’s annual budget. Human resources, especially in anesthesia, are among…
Gene therapy for long-term treatment of Pompe disease
Unmet Need Pompe disease is a rare heritable disorder impacting heart and skeletal muscle function with an estimated incidence rate of 1 in 40,000 births in the US. Of these affected births, a third take…
Method to enable cancer immune checkpoint therapy
Unmet Need Cancer remains to be a heavy burden on Americans as many current gold-standard treatments can be ineffective. In 2022, an estimated 623,000 Americans were living with metastatic cancer and is predicted to increase…
The ubiquitination status of the glucagon receptor determines signal bias
Unmet Need Currently, management of diabetes and other metabolic disorders lacks understanding of how the ubiquitination status of the glucagon receptor (GCGR) impacts its signaling pathways. Conventional approaches in targeting G protein-coupled receptors (GPCRs) for…