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An effective method for treating functional gastrointestinal and motility disorders using patterned electrical stimulation in the colon
Unmet Need Functional gastrointestinal and motility disorders (FGIMD) impact 1 in 5 persons in the U.S. It is a group of disorders classified by GI symptoms which include irritable bowel syndrome, fecal incontinence, constipation, and…
A new therapeutic target for preventing hair loss in chemotherapy-treated cancer patients
Unmet Need Losing one’s hair is a profoundly unnerving phenomenon that affects daily life, social relationships, and even one’s own confidence. While about 2% of the world’s population suffers from general hair loss, it is…
A method to enable the use of a novel biomarker for deep brain stimulation treatments
Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…
Methods and compositions for treating protein aggregation diseases
Unmet Need Neurodegenerative disease affects more than 50 million people per year. Certain neurodegenerative diseases, like Alzheimer’s disease, result from the accumulation of amyloid-forming proteins in the brain, which results in cognitive impairment and has…
A method to improve deep brain stimulation treatments by using cortical evoked potentials as a biomarker
Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…
A multi-electrode multiplexed channel brain-computer interface for patient assistive technologies
Unmet Need According to the WHO, in 2019 neurological disorders were recognized as a growing public health challenge resulting in over 500,000 deaths globally. In the US alone, neurological diseases cause an estimated $800 billion-dollar…
Breast cancer risk prediction technology using genomic classifier
Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…
Augmented Reality for Neurosurgery
Unmet Need Approximately 30% of the 3.5 million epilepsy patients in the United States struggle to control seizures despite receiving existing treatments. These patients often undergo neurosurgery to help alleviate their symptoms. Surgical planning involves…
Novel epigenome editors for multiplexed gene regulation
Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…
Intravesical UTI vaccine to induce bacteria-eradicating immune responses in the bladder
Unmet Need Urinary tract infections (UTI) are typically caused by uropathogenic E. coli (UPEC) that proliferate in urine and infect the urethra and bladder epithelial cells. UTIs represent the second most common bacterial infection in…
Torque Assisting Device for Endoscopy
Unmet Need Colorectal cancer is the third leading cause of cancer-related deaths in the United States. As a preventative measure, more than 15 million colonoscopies are performed in the United States each year. This common…