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RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment
Unmet Need Multiple myeloma (MM) is the second most common hematological malignancy in the United States. Although current anti-myeloma therapeutics help patients live with the disease for more than 10 years, MM remains an incurable…
Transgenic zebrafish to direct epicardial gene expression
Technology Duke inventors have generated a novel zebrafish model that allows researchers to study epicardial cells during embryonic heart development and myocardial regeneration. This zebrafish line is termed Tg(tcf21:CreER)pd42. Specifically, this transgenic model was created…
iPSC line to identify novel therapies for ARVC
Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…
Olfactory neuroblastoma mouse model
Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…
LpxH targeting antibiotics for Gram-negative bacteria
Unmet Need Antimicrobial resistance of bacteria to antibiotics is a major threat to public health. In 2019, 4.95 million deaths, 64% of all bacterial infection related deaths globally, were attributed to antimicrobial resistance to antibiotics.…
Human B2-adrenergic receptor CHW cell line
Technology Duke inventors have generated a chinese hamster fibroblast cell line that expresses the human β2–adrenegic receptor.
Long extra-corporeal arterial sheaths and catheters for coronary angiography and intervention
Value Proposition Percutaneous coronary interventions (PCI) such as angioplasty and angiography can be performed for therapeutic as well as diagnostic reasons. Over 20 million angiography and 10 million angioplasty procedures are projected to be performed…
Pancreatic cancer treatment that inhibits the Piezo1/TRPV4 axis
Unmet Need Pancreatic cancer has one of the highest mortality rates of all cancer types in the US. The American Cancer Society predicts that about 64,000 people will be diagnosed with pancreatic cancer and 55,000…
A method for end-to-end spatial accuracy quality assurance for radiosurgery
Unmet Need Radiation therapy is an essential element of cancer treatment that benefits 4 million diagnosed patients every year. The ability to deliver complex three-dimensional distributions of dose that conform to even irregularly shaped lesions…
Small molecule inhibitors of eHSP90 to treat autoimmune diseases
Unmet Need It is estimated that autoimmune diseases affect 1 out of every 10 individuals. These debilitating diseases are the result of the immune system inappropriately targeting and attacking the body. The resulting disease is…
T-cell releasing antibody for breast cancer tumor metastasis prevention
Unmet Need Metastatic breast cancer is a deadly form of breast cancer with only 1/3 of patients diagnosed with it living to 5 years post-diagnosis. Metastasis can occur either at disease onset (6% of patients)…
Wearable smart radiation reporting material
Unmet Need Excess radiation exposure can result in DNA damage and tissue injury. Individuals who are occupationally exposed to ionizing radiation need to monitor and track radiation exposures. Small, personal radiation dosimeters currently exist, but…