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Electro-stimulation device to promote bladder voiding
Value Proposition Despite its association with a diverse array of conditions and particularly high prevalence among the elderly, underactive bladder lacks reliable clinical treatment options. Many pharmacological treatments have proven ineffective and cause undesirable side…
Method for treating glycogen storage disease
The present disclosure is directed to methods of treating a cytoplasmic glycogen storage disorder, including glycogen storage disease I, glycogen storage disease III, glycogen storage disease IV, and/or conditions associated with a PRKAG2 mutation, by…
Pulse duration and the dynamics of infrared tissue ablation
Value Proposition Laser-based ablation procedures are being investigated as a minimally invasive form of surgery to treat several forms of cancerous as well as non-cancerous lesions in neuro-, ophthalmic-, and cardiothoracic-surgery. While several different types…
Mast cell targeting to predict and prevent virus-induced vascular leakage
Value Proposition Dengue is a mosquito spread virus that affects millions of people worldwide. According to the World Health Organization, there are approximately 390 million dengue virus infections each year, and it is the leading…
Molecular classifiers of bacterial infection
Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.
Miniaturized, ultra-high density, multichannel electrode array for long-term, intra-cranial neuronal recordings
Technology A high-density multichannel microwire electrode array is disclosed. The array can comprise a variable number of electrodes. A method of assembling the array is further disclosed. Additionally, a plurality of devices employing the array…
Providing surface contrast in rendering of three-dimensional images for micro-surgical applications
Value Proposition Recent advancements in optical coherence tomography (OCT) technology have greatly improved image quality and have facilitated the acquisition, processing, and display of three-dimensional information in real-time. As a result, this technology can now…
Techniques for the segmentation of layered structures using graph theory and dynamic programming
Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges.…
Targeting novel cytokine receptors for anti-cancer activity on human cancers
Researchers at Duke University have discovered novel mRNA isoforms of a cytokine receptor that are expressed in a variety of cancers, including breast and cervical cancer cells. They have created cell lines expressing these abnormal…
Shank3 knockout mice as a model for autism
The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated…
Conjugated neuroactive steroid compositions and methods of use thereof
The present disclosure provides modified neuroactive steroids. The modified neuroactive steroids may comprise, consist of, or consist essentially of a therapeutic agent and/or a modifying moiety. The modified neuroactive steroid can have modified characteristics as…
Model-based optimization of spinal cord stimulation parameters
Value Proposition Spinal cord stimulation (SCS) is an FDA approved therapy for treating chronic lower back and limb pain. SCS is based on the gate control theory of pain, where an implanted pulse generator delivers…