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Methods to utilize microbial organisms in the gut to modulate neurological responses
Unmet Need The gut is home to dynamic bacterial communities that shape the behavior of the host. The food we eat, our changes in mood, and even some of our social behaviors correlate with shifts…
Chemical modulators of immune checkpoints and cell growth for cancer treatment
Unmet Need Each year there are over 1.6 million new cases of cancer in the US, and over 600,000 cases prove fatal. Treating various types of cancer can be particularly challenging because of the complex…
Using oxidative cell death to target RB1-deficient prostate cancer
Unmet Need In the first quarter of 2023, there were approximately 288,300 Americans diagnosed with prostate cancer, accounting for about 15% of all new cancer diagnoses. The five-year survival rate of patients with prostate cancer…
Method for streamlining deep brain stimulation control parameters determination in Parkinson’s Disease
Unmet Need Parkinson’s disease (PD) is estimated to impact 10 million people worldwide. Currently, there are no cures for the disease. While treatments have significantly improved symptoms in patients, side effects of the pharmaceutical treatments…
Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis
Unmet Need Driven by the rising tide of obesity and lack of medical treatment, it is estimated that 1 out of 4 adults in the US has non-alcoholic fatty liver disease or non-alcoholic steatohepatitis (NAFLD/NASH).…
Methods and formulation to improve cellular survival of thawing after cryopreservation
Unmet Need Cryopreservation is the main method of long-term storage and transport of living cells, and it is used for cell lines and patient samples such as stem cells, CAR-T cells, bone marrow, cord blood,…
A device for clinical wet-to-wet connections that alleviates healthcare provider anxiety and enhances patient quality of care
Unmet Need Extracorporeal membrane oxygenation (ECMO) is a rapidly growing method of providing life-saving support to a patient suffering from heart or lung failure. Between 2010 and 2021 ECMO runs in the United States grew…
A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals
Unmet Need In the past three decades implanted neurostimulation devices have become widely adopted driven largely by their ability to treat a range of clinical conditions with a “drug-free” solution. The $6.6 billion dollar market…
A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy
Unmet Need Cancer immunotherapy provides great advantages over traditional cytotoxic chemotherapy and radiation with more durable clinical outcomes and an improved quality of life. The number of US patients eligible for immunotherapy was estimated to…
HIV treatment and prevention using broadly neutralizing antibodies
Unmet Need For over 40 years, the human immunodeficiency virus (HIV) pandemic has affected the quality of life and decreased the life expectancy for millions of people with approximately 1.5 million new cases each year.…
Implant for identifying sites of seizure onset in the brain
Unmet Need In the United States, epilepsy affects 2.2 million people with 150,000 new cases each year. Between 14.6% and 36.3% of people who suffer from epilepsy have forms of epilepsy that are not controllable…
Method to overcome treatment resistant cancer by rescuing STING signaling
Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…