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Novel Method for Treating Steatosis-Associated Diseases
Unmet Need Steatosis-associated diseases are marked by the infiltration of the liver with fatty acids. This can occur in disease backgrounds such as glycogen storage disease (GSD), nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis…
Novel epigenome editors for multiplexed gene regulation
Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…
Method for immune tolerance induction in patients receiving enzyme replacement therapy for a variety of metabolic disorders
Unmet Need Genetically based metabolic disorders affect 1 in 2500 births globally and many of these disorders result in an enzyme deficiency. In most cases, a single enzyme is not produced by the body at…
HIV treatment and prevention using broadly neutralizing antibodies
Unmet Need For over 40 years, the human immunodeficiency virus (HIV) pandemic has affected the quality of life and decreased the life expectancy for millions of people with approximately 1.5 million new cases each year.…
Acoustofluidic technologies for precision control in microfluidic systems
Unmet Need Achieving precise manipulation of particles, cells, and droplets in microscale liquid systems is a major challenge in life sciences, material sciences, and chemistry. Traditional microfluidic systems, which use hydrophobic channels and pressure differentials…
Molecular Classifiers of Bacterial Infection
Unmet Need Bacterial infections can lead to various outcomes, with septicemia posing significant morbidity and mortality risks for patients. Septicemia occurs when bacteria enter and spread through the bloodstream, triggering an extreme immune response in…
Gene expression signature to predict sepsis mortality
Unmet Need Sepsis is responsible for half of the in-hospital deaths in the US. It is characterized by organ dysfunction resulting from an uncontrolled response to an infection. The standard treatment for sepsis includes source…
Identification and application of novel lipoglycodepsipeptide antibiotics
Unmet Need Antibiotic resistance (ABR) is a global public health concern. In 2019, an estimated five million deaths were attributed to antibiotic resistant pathogens. A recent study estimates that ABR could cause nearly ten million…
Gene signature for prediction of acute rejection in kidney transplant
Unmet Need Kidney transplant is the best current treatment for kidney failure. The kidney is the most common organ to be transplanted, and in 2019 there were 23,405 kidney transplants in the United States. Unfortunately,…
Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…
FK520 analogs modified to increase fungal specificity with applications in antifungal therapy
Unmet Need Fungal infections are becoming more prevalent worldwide, with 150 million cases and 1.7 million fatalities reported in the last year alone. These are largely caused by multi-drug-resistant fungi, which makes treatment more challenging.…
The Air-X Syringe: using airway loss of resistance for safer cricothyroidotomies
Unmet Need Between 13-20 million tracheal intubations are performed in the US each year, including surgical and emergency intubations. When the upper airway is obstructed, a needle cricothyroidotomy can be used to insert a catheter…