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Probiotic-based prevention of respiratory infections
Unmet Need Pneumonia is the leading infectious killer of children, causing over 800,000 deaths annually. Streptococcus pneumoniae remains a major driver of these fatalities, even with widespread vaccination. Current vaccines are insufficient to address all…
Rapid, responsive, and active dissection insertion device for large-bore chest tubes
Unmet Need Tube Thoracostomy, a critical procedure for removing fluids and/or air from around the lungs to restore breathing, has a high complication rate of 30%, with complications increasing cost by up to 21x. This…
The Air-X Syringe: using airway loss of resistance for safer cricothyroidotomies
Unmet Need Between 13-20 million tracheal intubations are performed in the US each year, including surgical and emergency intubations. When the upper airway is obstructed, a needle cricothyroidotomy can be used to insert a catheter…
Cell and animal models of pulmonary fibrosis
Unmet Need Pulmonary fibrosis is an irreversible and progressive disease characterized by the buildup of fibrotic material in the lungs, reducing lung function. There are over 200 different types of pulmonary fibrosis resulting from numerous…
Intubation tent to protect healthcare workers from infected patients
Value Proposition Under the current COVID crisis, health care workers need protection against respiratory infections transmitted by patients undergoing treatment. Patients undergoing intubation for surgery or prior to being placed on a ventilator can expose…
Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury
Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…
Strengthening a patient’s immune functions to prevent infectious diseases without developing antibiotic resistance
Unmet Need Despite the development of numerous antibiotics over the years, the arms race between humans and emergent antibiotic-resistant microbes remains. More than 2.8 million antibiotic-resistant infections and 35,000 deaths occur in the U.S. each…
Molecular diagnostic test for acute respiratory viral infections
Unmet Need Acute respiratory viral (ARV) infections are among the most common reasons for patient visits in primary and acute care settings. ARV can be caused by many viruses including human rhinovirus (HRV), respiratory syncytial…
Targeting hyaluronan, CD44 and lung fibroblast invasion to block fibrogenesis
Value Proposition Idiopathic pulmonary fibrosis (IPF) is the most common type of pulmonary fibrosis. Scarring causes stiffness in the lungs and makes it difficult to breathe. Currently, more than 80,000 adults in the United States…