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Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 22.0% predicted to occur until 2024. Medical and dental products account for about…
Targeted Ablation and Replacement of Sertoli Cells for Infertility Treatment
Value Proposition Infertility affects 10-15% of couples, with up to 50% of cases attributed to male factors. While 30% of male infertility cases are idiopathic, around 5-10% of cases are believed to be linked to…
An organ chip model of the mammalian joint
Unmet Need Human movement relies on the function of cartilage-containing joints. In conditions such as osteoarthritis (OA), the cartilage within the joints becomes inflamed and degrades, leading to intense debilitating pain when bending joints. Despite…
Gene therapy for long-term treatment of GSDIa
Unmet Need Glycogen storage disease type Ia (GSDIa), or von Gierke disease, is a rare heritable metabolic disorder that impacts the liver and kidneys due to an inability to break down glycogen. An estimated 1…
A method for treating critical limb ischemia and other ischemic injuries
Unmet Need The most severe stage of peripheral artery disease, a chronic vascular disease characterized by impaired circulation to patients’ lower extremities, is critical limb ischemia (CLI), and it affects approximately two million people in…
An injectable hydrogel scaffold that delivers gene therapies locally
Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…
An implanted biomaterial to accelerate bone healing
Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…
Lowering ApoE to improve age-related bone fracture healing
Value Proposition Bone fractures occur in 50% of the population, causing significant morbidity and mortality and costing the US health care system over $20 billion annually. Complications, such as nonunion or delayed union, occur in…
Genetically encoded hybrid biomaterials that are thermally responsive and tunable
Unmet Need Developing new biomaterials is an active area of research, with applications in tissue engineering, regenerative medicine, and drug-delivery. In particular, protein- and peptide-based materials are attractive candidates for these applications because of their…