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Tunable elastomer-like polymers for use in soft tissue regeneration and drug delivery
Unmet Need Biodegradable synthetic polymers are often used as scaffolding or support materials in tissue engineering and regenerative medicine. However, many of the materials that have been used widely, such as PLLA and PCL, do…
Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 22.0% predicted to occur until 2024. Medical and dental products account for about…
Biomaterial therapy for healing brain tissue after ischemic stroke
Unmet Need Ischemic stroke affects 692,000 patients annually in the United States, and can result in paralysis and complications related to cognition and motor function. After a stroke, scarring and atrophy can occur at the…
Biomaterial pouch for long-term xenogeneic cell transplantation
Unmet Need Cell therapy is an exciting therapeutic approach that is growing rapidly – there are more than 1,000 cell therapy clinical trials that are currently active in many different fields like oncology, neurology, hematology,…
A method for treating critical limb ischemia and other ischemic injuries
Unmet Need The most severe stage of peripheral artery disease, a chronic vascular disease characterized by impaired circulation to patients’ lower extremities, is critical limb ischemia (CLI), and it affects approximately two million people in…
An injectable hydrogel scaffold that delivers gene therapies locally
Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…
An implanted biomaterial to accelerate bone healing
Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…
Genetically encoded hybrid biomaterials that are thermally responsive and tunable
Unmet Need Developing new biomaterials is an active area of research, with applications in tissue engineering, regenerative medicine, and drug-delivery. In particular, protein- and peptide-based materials are attractive candidates for these applications because of their…
Pharmacological approach to induction of mitochondrial biogenesis for rapid maturation and functional differentiation of stem/progenitor cells in the heart and other tissues
Value Proposition Following heart disease diagnosis, traditional therapies seek to limit further damage to the heart and, ultimately, to prevent the development of heart failure and death. However, current therapies do little to reverse the…
Methods for ablating niche cells in testis
Value Proposition Infertility affects 10-15% of couples and up to 50% of these cases are due to the male partner. While the largest proportion (30%) of these cases are idiopathic with no known causes and…