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The Fit Together Playbook: a curriculum that fosters community partnerships to fight child obesity

The Fit Together Playbook: a curriculum that fosters community partnerships to fight child obesity

Unmet Need Childhood obesity affects 1 in 5 children resulting in more than 14.7 million obese children ages 2-19 years old in the United States. Many factors can contribute and cause obesity including diet, lack…

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iPSC line to identify novel therapies for ARVC

iPSC line to identify novel therapies for ARVC

Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…

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Gene therapy for long-term treatment of Pompe disease

Gene therapy for long-term treatment of Pompe disease

Unmet Need Pompe disease is a rare heritable disorder impacting heart and skeletal muscle function with an estimated incidence rate of 1 in 40,000 births in the US. Of these affected births, a third take…

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Gene therapy for ATP1A3-Related Neurologic Disorders

Gene therapy for ATP1A3-Related Neurologic Disorders

Unmet Need Children with Alternating Hemiplegia of Childhood can have episodes of temporary paralysis, dystonia, and severe behavioral problems. The prevalence of AHC is estimated to be 1 in one million to 1 out of…

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Automatic segmentation software to diagnose retinopathy of prematurity (ROP) from optical coherence tomography images in preterm infants

Automatic segmentation software to diagnose retinopathy of prematurity (ROP) from optical coherence tomography images in preterm infants

Unmet Need Retinopathy of prematurity (ROP) is a developmental vascular proliferative disorder that occurs in approximately 50-70% of preterm infants and is a leading cause of childhood blindness. The most critical factor in identifying ROP…

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Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Unmet Need Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for critically ill patients with low oxygen levels. During ECMO, the patient’s blood flows through an external oxygenation device. This requires co-treatment with an anticoagulant…

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The Trail Guide curriculum for childhood obesity treatment program model

The Trail Guide curriculum for childhood obesity treatment program model

Unmet Need Childhood obesity is an ongoing health concern involving cardiometabolic risk, reduced quality of life and long-term health consequences. Current child obesity treatment guidelines recommend 26 or more hours of behavior treatment, delivered over…

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A method of screening and monitoring glycogen storage diseases with a single biomarker

A method of screening and monitoring glycogen storage diseases with a single biomarker

Unmet Need Glycogen storage disease type I (GSD I) is an autosomal recessive inherited disorder of carbohydrate metabolism associated with life threatening fasting hypoglycemia, and significant morbidity and mortality. Currently, the standard of care therapy…

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