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New small molecules targeting castration-resistant prostate cancer
Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…
Topical MEK inhibition as a new modality for inflammatory skin diseases and cancers
Unmet Need Inflammatory skin conditions affect many people, with a wide range of severities. Common skin disorders, such as psoriasis and atopic dermatitis, affect close to 20% of the population. Skin lesions associated with bone…
Method to sensitize cancer radiotherapy and chemotherapy
Unmet Need While radiotherapy and/or chemotherapy are used for >90% of cancer patients in clinical settings, the therapeutic outcomes are far from ideal for many types of tumors due to the development of drug resistance…
A class of biodegradable stealth polymers to improve drug delivery
Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…
A method for treating TRAIL-resistant cancers
Unmet Need Over the past twenty years, TNF-related apoptosis-inducing ligand (TRAIL) has been shown to kill a variety of human cancer cells in vitro and in vivo while remaining innocuous to healthy cells. Unfortunately, the…
A tumor-targeting delivery method for chemotherapeutics and other cargo
Unmet Need Delivery and therapeutic efficacy of small molecule imaging agents and chemotherapeutics are hampered by their short half-life, low solubility, non-selectivity to cancer cells, and toxic side effects. Small molecule chemotherapeutics, although in routine…
A nanoparticle drug delivery system for small molecule cancer drugs that binds endogenous albumin
Unmet Need Small molecule cancer drugs often suffer from poor systemic exposure, resulting from their low water solubility and short plasma half-life. Additionally, the off-target toxicity is the main challenge that undermines efficacy. Nanoparticle drug…
Targeting drugging molecules that promote cancer metastasis
Value Proposition Metastases, the spread of cancer cells to new areas of the body, are common and devastating complications of many kinds of cancers. For instance, bone metastasis occurs in 73% of advanced breast cancer…
Avicins and thioesterification to control protein function
Value Proposition Thioesterification agents can modify cysteine groups of signaling proteins in order to modify their activity. Pathologies that could benefit from such protein modifications, which modulate physiologic redox status, include atherosclerosis, cancer, bacterial infections,…
Novel therapeutic targets in the androgen receptor signaling pathway for prostate cancer
Unmet Need Prostate cancer is the most common malignancy in men. The most recent CDC data demonstrates that prostate cancer makes up 12.2% all new cancer cases in the U.S. at 207,430. Prostate cancers express…
A rod-like nanoparticle drug delivery system for hydrophilic small molecules
Unmet Need New strategies to load small molecule drugs into nanoparticles are a powerful approach to improve the therapeutic efficacy of chemotherapeutics, and this has been a successful strategy for overcoming the limitations of poor…
Improving immune checkpoint therapies for cancer by inhibiting the PCSK9 protein
Value Proposition Immune checkpoint inhibitor therapies are exciting new drugs for treatment of cancers. Despite their efficacy for certain cancers, immune checkpoint inhibitors only effective in 10-30% of cancer patients. Because of this, there is…