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Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…
Breast cancer risk prediction technology using genomic classifier
Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…
A robust and sensitive assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts
Unmet Need Cis-regulatory elements (cREs) of the genome are non-coding regions that play essential roles in regulating gene expression in development and disease. Importantly, these regions are characterized by the presence of “open” chromatin and…
CRISPR-based antiviral treatment of coronavirus infections
Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…
A CRISPR-based system for modifying the length of 3’ untranslated regions (3’UTR) of an mRNA transcript that offers novel treatment strategies for prostate cancer and other diseases
Unmet Need Abnormal length changes in the 3’ untranslated region (3’UTR) of mRNAs are associated with many diseases such as systemic lupus erythematosus, α-thalassemia, facioscapulohumeral muscular dystrophy, and cancer. While existing technologies can manipulate expression…
Optical device for in vivo assessment of tissues
Value Proposition Fluorescence and diffuse reflectance spectroscopy in the ultraviolet-visible (UV-VIS) spectrum are increasingly being investigated for tissue characterization. These biological scatterers, absorbers, and fluorophores may be used to indicate the existence of certain diseases.…
Isogenic HCT116 cell lines with heterozygous or homozygous IDH1R132H mutation
Value Proposition One of the major challenges in studying the implications of the IDH1 mutations has been the dearth of cell line models which recapitulate IDH mutation-dependent tumor progression. Technology Researchers at Duke have generated…
MP399 Cell Line
MP399 is a fully characterized myeloma cell line established from a patient with plasma cell leukemia. It has been successfully used to test a drug with anti-myeloma activity in-vitro. Subsequently and based on our preliminary…
A 3D tissue model for evaluating lymphovascular invasion of breast cancer cells
Value proposition Tissue engineering is an emerging market expected to witness significant growth over the next few years, with a CAGR of approximately 34.9%. There are many applications of tissue engineering, including the development of…
A cDNA sequence encoding the ATX protein (Human ATX cDNA)
Value Proposition ATX is an active protein kinase that plays a role in cellular stress responses, and defects in ATX also play a role in the development of cancer and other proliferative disorders. Thus, small…
Rapid immunoassay to detect anti-EGFRviii levels to evaluate vaccine efficacy
Value Proposition Tumor-specific molecules offer the possibility of targeted cancer therapy using monoclonal antibodies (mAbs) specifically directed against the tumor-specific molecule. However, it has proven difficult to identify tumor-specific molecules. Overexpression of EGFR in human…