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A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy

A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy

Unmet Need Cancer immunotherapy provides great advantages over traditional cytotoxic chemotherapy and radiation with more durable clinical outcomes and an improved quality of life. The number of US patients eligible for immunotherapy was estimated to…

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Method to overcome treatment resistant cancer by rescuing STING signaling

Method to overcome treatment resistant cancer by rescuing STING signaling

Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…

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A new therapeutic target for preventing hair loss in chemotherapy-treated cancer patients

A new therapeutic target for preventing hair loss in chemotherapy-treated cancer patients

Unmet Need Losing one’s hair is a profoundly unnerving phenomenon that affects daily life, social relationships, and even one’s own confidence. While about 2% of the world’s population suffers from general hair loss, it is…

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Breast cancer risk prediction technology using genomic classifier

Breast cancer risk prediction technology using genomic classifier

Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…

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Torque Assisting Device for Endoscopy

Torque Assisting Device for Endoscopy

Unmet Need Colorectal cancer is the third leading cause of cancer-related deaths in the United States. As a preventative measure, more than 15 million colonoscopies are performed in the United States each year. This common…

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A synergistic chemotherapy and radiotherapy drug delivery technology for treating prostate cancer tumors

A synergistic chemotherapy and radiotherapy drug delivery technology for treating prostate cancer tumors

Unmet Need Pancreatic cancer is one of the deadliest manifestations of cancer in clinical oncology. Despite accounting for only 3.2% of all cancer cases, it is the third leading cause of cancer-related mortality. National Comprehensive…

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Fiber optic probe with integrated photodetector capabilities

Fiber optic probe with integrated photodetector capabilities

Unmet Need Light-based diagnostics is a non-intrusive procedure that can be used to monitor chemotherapy treatment efficacy. Optical imaging additionally has the capacity for roles in diagnosis and surgery guidance. Currently, many devices for optic…

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A robust and sensitive assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts

A robust and sensitive assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts

Unmet Need Cis-regulatory elements (cREs) of the genome are non-coding regions that play essential roles in regulating gene expression in development and disease. Importantly, these regions are characterized by the presence of “open” chromatin and…

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A low-cost and effective ethanol ablation tumor treatment

A low-cost and effective ethanol ablation tumor treatment

Unmet Need Cervical cancer is the fourth most common cancer among woman globally, with an estimated 342,000 deaths in 2020, of which 90% of deaths occurred in low-and middle-income countries. A primary reason for this…

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A genomics-based method to identify candidates for cancer treatment

A genomics-based method to identify candidates for cancer treatment

Unmet Need Metastatic cancer accounts for up to 90% of all cancer deaths in the United States. Treatment at advanced stages of various cancers include immune checkpoint blockade therapy, targeted tumor therapy, cytotoxic chemotherapy, and…

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Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors

Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors

Unmet Need Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL, CD253) acts as an activator of apoptosis in many tumor cells, while remaining innocuous to normal cells. Both membrane-bound and soluble forms of TRAIL can trigger apoptosis…

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Endocrine cancer treatment method using glycerate

Endocrine cancer treatment method using glycerate

Unmet Need Endocrine cancers, those that affect organs that secrete hormones, are among the most common cancers in the U.S. Tumors that form in the organs of the endocrine system often secrete excess hormones or…

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