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Induction of immunogenic cell death in cancer cells using modified ssRNAs
Value proposition Cancer immunotherapy is showing great promise against numerous cancer types in clinical trials. Consequently, this market is projected to rapidly grow to over $200 billion by 2021. Among the list of effective immunotherapies…
Novel mutation-resistant smoothened inhibitors for cancer therapy
Value Proposition The hedgehog signaling pathway is an important mediator of developmental and cellular differentiation processes in both embryonic and adult tissues, but can also promote tumor growth and progression if dysregulated. Two forms of…
Discovery of a potent and selective inhibitor of DAPK1 and ZIPK
Value Proposition The DAPK family, including Zipper-interacting protein kinase (ZIPK), mediates cell death through the transmission of apoptotic and autophagic signals. This family of kinases also regulates both non-muscle and smooth muscle myosin phosphorylation. Another…
Optimization of fiber optic probes for spectroscopic measurements
Value Proposition Early detection of cancer greatly increases the chances for a positive outcome. The World Health Organization states that there are two major components of early detection of cancer: increased awareness and screening. Diffuse…
Diagnostic and treatment for chronic and acute phase myeloid leukemia
Value Proposition While cancer therapies have increased survival for many tumor types, the reality is that 50-60% of cancer patients will die from the disease. This highlights a need for the continued search for targeted…
Development of novel therapeutic splice-switching oligonucleotides against aggressive prostate cancer
Value Proposition One in twelve men will be diagnosed with prostate cancer in their lifetime. Castration resistant prostate cancer, which resists traditional hormone therapies and continues to grow and often metastasize with poor survival outcomes,…
SUMO as a marker of cancer development and target for cancer therapy
Value Proposition Cancer therapy remains challenging, and the production of new inhibitor therapies is stinted by the need for clear successful targets that will block tumor cell proliferation. Small ubiquitin-like modifier (SUMO) proteins and the…
Mice carrying functional single nucleotide polymorphisms in brain-specific trytophan hydroxylase(Tph2)
We have developed mice expressing 2 different mutant alleles of the brain-specific tryptophan hydroxylase gene (Tph2). Tryptophan hydroxylase is the rate limiting enzyme involved in the synthesis of serotonin. These mice have significantly reduced levels…
Blood-based biomarkers for colon cancer
Value Proposition Of cancers that affect both men and women, colorectal cancer is the second leading cancer killer in the United States. Agents that inhibit either VEGF signaling pathways or mitogenic signaling through the epidermal…
CD3/CD28 costimuled and expanded cord blood T lymphocytes can be primed by killed leukemic cells to generate cytotoxic lymphocytes (CTL) available for adoptive immunotherapy against leukemia
Value Proposition Allogenic hematopoietic cell transplant (bone marrow or stem cell transplantation) is a therapy method used on hematology-related cancers and various autoimmune diseases. This therapy method has proven to be widely successful and one…