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Improving the efficacy of anti-PD-1 antibody immunotherapy
Value Proposition Despite the significant impact that the checkpoint inhibitor immunotherapies have generated in clinical oncology, the majority of our cancer patients still do not benefit from this treatment modality. While the PD-1/PD-L1 system plays…
Components of the Wnt-Beta-catenin paracrine signaling pathway as predictive biomarkers for cancer immunotherapy
Value Proposition Immunotherapy is a promising approach for the treatment of many cancers. However, despite early success, majority of patients with advanced cancer fail to respond or become resistant. In even the most immunogenic cancer…
Optical assay system for intra operative assessment of tumor margins
Researchers at Duke University have developed a new optical device that differentiates cancer from normal tissues by measuring tissue composition, and meets the intraoperative performance requirement that surgeons demand. The surgeon surveys the tumor surface…
A diagnostic test for differentiating follicular thyroid adenoma for follicular thyroid carcinoma
Duke University is seeking a company interested in commercializing a novel method to distinguish follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC). Global estimates of thyroid cancer incidence for 2006 indicate half a million…
Targeting novel cytokine receptors for anti-cancer activity on human cancers
Researchers at Duke University have discovered novel mRNA isoforms of a cytokine receptor that are expressed in a variety of cancers, including breast and cervical cancer cells. They have created cell lines expressing these abnormal…
Chemical modulators of immune checkpoints and therapeutic use
Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The…
An effective FASN inhibitor
Value Proposition Many tumors are dependent on de novo fatty acid synthesis as a source of long chain fatty acids to maintain growth and interdicting at key steps in this pathway may have therapeutic benefit.…
Novel mutation-resistant smoothened inhibitors for cancer therapy
Value Proposition The hedgehog signaling pathway is an important mediator of developmental and cellular differentiation processes in both embryonic and adult tissues, but can also promote tumor growth and progression if dysregulated. Two forms of…
Discovery of a potent and selective inhibitor of DAPK1 and ZIPK
Value Proposition The DAPK family, including Zipper-interacting protein kinase (ZIPK), mediates cell death through the transmission of apoptotic and autophagic signals. This family of kinases also regulates both non-muscle and smooth muscle myosin phosphorylation. Another…
Optimization of fiber optic probes for spectroscopic measurements
Value Proposition Early detection of cancer greatly increases the chances for a positive outcome. The World Health Organization states that there are two major components of early detection of cancer: increased awareness and screening. Diffuse…
Diagnostic and treatment for chronic and acute phase myeloid leukemia
Value Proposition While cancer therapies have increased survival for many tumor types, the reality is that 50-60% of cancer patients will die from the disease. This highlights a need for the continued search for targeted…
Development of novel therapeutic splice-switching oligonucleotides against aggressive prostate cancer
Value Proposition One in twelve men will be diagnosed with prostate cancer in their lifetime. Castration resistant prostate cancer, which resists traditional hormone therapies and continues to grow and often metastasize with poor survival outcomes,…