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Gene therapy and small molecule treatment of chronic pain without addiction
Unmet Need Chronic pain is an escalating issue worldwide – in the U.S., an estimated one of five adults are affected. Chronic pain is difficult to treat, often requiring powerful opioids to provide relief. These…
CRISPR-based antiviral treatment of coronavirus infections
Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…
Machine learning algorithm to predict malignancy in thyroid nodules
Value Proposition An estimated 10% of the general population in the United States are expected to develop a thyroid nodule in their lifetime. Although the vast majority of thyroid nodules are noncancerous, a small proportion…
A focal hypothermia device to slow down tumor growth
Unmet Need Malignant brain tumors such as glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG) progress rapidly and can be fatal. Median survival for these cancers is on the order of 15-18 months with…
A method of identifying a B cell malignancy as Hodgkin’s Lymphoma
Unmet Need Malignancies derived from mature B cells are common and constitute the majority of blood cancers. The biology of these leukemias and lymphomas reflect defined stages of normal B-cell differentiation. Correct diagnosis of B…
A class of biodegradable stealth polymers to improve drug delivery
Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…
A method for treating TRAIL-resistant cancers
Unmet Need Over the past twenty years, TNF-related apoptosis-inducing ligand (TRAIL) has been shown to kill a variety of human cancer cells in vitro and in vivo while remaining innocuous to healthy cells. Unfortunately, the…
A CRISPR-based system for modifying the length of 3’ untranslated regions (3’UTR) of an mRNA transcript that offers novel treatment strategies for prostate cancer and other diseases
Unmet Need Abnormal length changes in the 3’ untranslated region (3’UTR) of mRNAs are associated with many diseases such as systemic lupus erythematosus, α-thalassemia, facioscapulohumeral muscular dystrophy, and cancer. While existing technologies can manipulate expression…
Systems and methods for automatic radiation treatment plan generation and evidence-based customization for breast cancer
Unmet Need Breast cancer is now the most commonly diagnosed form of the disease, with 2.3 million new cases in 2020. Some of the most effective therapies for cancer are based around beams of radiation…
System and method for automated fluence map prediction and radiation treatment plan generation
Unmet Need Cancer is a leading cause of death worldwide, with almost 10 million deaths and over 19 million new cases in 2020. These numbers are expected to grow, with 28 million new cases estimated…
Systems and methods for automated radiation treatment planning with decision support
Unmet Need Cancer is a leading cause of death worldwide, with almost 10 million deaths and over 19 million new cases in 2020. These numbers are expected to grow, with 28 million new cases estimated…
Systems and methods for learning and accumulating optimal strategies for radiation treatment planning
Unmet Need Cancer is a leading cause of death worldwide, with almost 10 million deaths and over 19 million new cases in 2020. These numbers are expected to grow, with 28 million new cases estimated…