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A low-cost and effective ethanol ablation tumor treatment
Unmet Need Cervical cancer is the fourth most common cancer among woman globally, with an estimated 342,000 deaths in 2020, of which 90% of deaths occurred in low-and middle-income countries. A primary reason for this…
A genomics-based method to identify candidates for cancer treatment
Unmet Need Metastatic cancer accounts for up to 90% of all cancer deaths in the United States. Treatment at advanced stages of various cancers include immune checkpoint blockade therapy, targeted tumor therapy, cytotoxic chemotherapy, and…
Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors
Unmet Need Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL, CD253) acts as an activator of apoptosis in many tumor cells, while remaining innocuous to normal cells. Both membrane-bound and soluble forms of TRAIL can trigger apoptosis…
Endocrine cancer treatment method using glycerate
Unmet Need Endocrine cancers, those that affect organs that secrete hormones, are among the most common cancers in the U.S. Tumors that form in the organs of the endocrine system often secrete excess hormones or…
An artificial intelligence powered direct prediction model of machine parameters to enhance patient specific pre-treatment during radiation therapy
Unmet Need Intensity modulated radiation therapy (IMRT) and volumetric modulated radiation therapy (VMAT) are commonly used radiation therapy techniques that are characterized by their highly conformal dose distributions and require pre-treatment quality assurance to ensure…
Topical MEK inhibition as a new modality for inflammatory skin diseases and cancers
Unmet Need Inflammatory skin conditions affect many people, with a wide range of severities. Common skin disorders, such as psoriasis and atopic dermatitis, affect close to 20% of the population. Skin lesions associated with bone…
All dielectric absorber for improved real-time imaging in the terahertz spectrum
Value Proposition Discoveries over the past decades have unveiled unique characteristics of the far-infrared or terahertz (THz) spectrum spanning from 0.3 THz to 10 THz, including non-ionization of biological materials, easy penetration into dielectric and…
Genomic Biomarkers of Locally Advanced Breast Cancer (LABC) and Inflammatory Breast Cancer (IBC)
Unmet Need Locally advanced breast cancer (LABC) and inflammatory breast cancer (IBC) are associated with high 5-year mortality rates (respectively 55% and 33%), especially when compared to early-stage breast cancers (~80%). LABC and IBC are…
A genomics-based method to identify cancer patients that will benefit from immune checkpoint therapy
Unmet Need Non-small-cell lung cancer accounts for 82% of all lung cancer diagnoses. Immune checkpoint blockade treatment is an exciting new course of action among advanced stage non-small-cell lung cancer patients. However, only a minority…
Method to regulate tumor growth and immunosuppression by GABA inhibition
Unmet Need Non-small cell lung cancer has an incidence of more than 200,000 cases with a survival rate of less than 50%. There are nearly 150,000 new cases of colorectal cancer each year and more…
Method to sensitize cancer radiotherapy and chemotherapy
Unmet Need While radiotherapy and/or chemotherapy are used for >90% of cancer patients in clinical settings, the therapeutic outcomes are far from ideal for many types of tumors due to the development of drug resistance…
Melanoma treatment method using estrogen modulating small molecules
Unmet Need Metastatic melanoma, skin cancer that has spread, is an incredibly deadly cancer, with a median survivorship of 6-9 months. For patients with melanoma, a frequently used therapy is immune checkpoint blockade (ICB). These…